Transforming growth factor-β in renal disease

被引：62

作者：

Bitzer, M

Sterzel, RB

Böttinger, EP

机构：

[1] Friedrich Alexander Universitat Erlangen Nurnberg, Med Klin & Poliklin 4, D-91054 Erlangen, Germany

[2] Albert Einstein Coll Med, Div Nephrol, Bronx, NY 10467 USA

来源：

KIDNEY & BLOOD PRESSURE RESEARCH | 1998年 / 21卷 / 01期

关键词：

transforming growth factor-beta; kidney; fibrosis; inflammation; animal models; transgenic mice; gene targeting;

D O I：

10.1159/000025837

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

An extensive number of animal and clinical studies indicate that transforming growth factors-beta (TGF-beta s)play an important role in inflammatory and fibrotic diseases, including renal fibrosis. Recent mouse models harboring genetically engineered alterations in TGF-P pathways reveal complicated mechanisms of regulation of TGF-beta activity in vivo. The purpose of this review is to present recent advances relevant to our understanding of the TGF-beta-signaling system in renal physiology and pathophysiology.

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页码：1 / 12

页数：12

相关论文

共 139 条

[1]

Abboud HE, 1997, KIDNEY INT, pS3

[2] Inhibition of TGF-beta 1 expression by antisense oligonucleotides suppressed extracellular matrix accumulation in experimental glomerulonephritis [J].

Akagi, Y ;

Isaka, Y ;

Arai, M ;

Kaneko, T ;

Takenaka, M ;

Moriyama, T ;

Kaneda, Y ;

Ando, A ;

Orita, Y ;

Kamada, T ;

Ueda, N ;

Imai, E .

KIDNEY INTERNATIONAL, 1996, 50 (01) :148-155

[3] THE ROLE OF TGF-BETA-S IN MAMMALIAN DEVELOPMENT AND NEOPLASIA [J].

AKHURST, RJ ;

FITZPATRICK, DR ;

FOWLIS, DJ ;

GATHERER, D ;

MILLAN, FA ;

SLAGER, H .

MOLECULAR REPRODUCTION AND DEVELOPMENT, 1992, 32 (02) :127-135

[4] TRANSFORMING GROWTH-FACTOR-BETA AS A PREDICTOR OF LIVER AND LUNG FIBROSIS AFTER AUTOLOGOUS BONE-MARROW TRANSPLANTATION FOR ADVANCED BREAST-CANCER [J].

ANSCHER, MS ;

PETERS, WP ;

REISENBICHLER, H ;

PETROS, WP ;

JIRTLE, RL .

NEW ENGLAND JOURNAL OF MEDICINE, 1993, 328 (22) :1592-1598

[5]

Bacus SS, 1996, AM J PATHOL, V148, P549

[6] Latency and Activation in the Control of TGF-β [J].

Barcellos-Hoff, Mary Helen .

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 1996, 1 (04) :353-363

[7]

BARCELLOSHOFF MH, 1995, AM J PATHOL, V147, P1228

[8] Mapping of a major genetic modifier of embryonic lethality in TGF beta 1 knockout mice [J].

Bonyadi, M ;

Rusholme, SAB ;

Cousins, FM ;

Su, HC ;

Biron, CA ;

Farrall, M ;

Akhurst, RJ .

NATURE GENETICS, 1997, 15 (02) :207-211

[9] SUPPRESSION OF EXPERIMENTAL GLOMERULONEPHRITIS BY ANTISERUM AGAINST TRANSFORMING GROWTH FACTOR-BETA-1 [J].

BORDER, WA ;

OKUDA, S ;

LANGUINO, LR ;

SPORN, MB ;

RUOSLAHTI, E .

NATURE, 1990, 346 (6282) :371-374

[10] NATURAL INHIBITOR OF TRANSFORMING GROWTH-FACTOR-BETA PROTECTS AGAINST SCARRING IN EXPERIMENTAL KIDNEY-DISEASE [J].

BORDER, WA ;

NOBLE, NA ;

YAMAMOTO, T ;

HARPER, JR ;

YAMAGUCHI, Y ;

PIERSCHBACHER, MD ;

RUOSLAHTI, E .

NATURE, 1992, 360 (6402) :361-364

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