The so-called bile duct adenoma is a peribiliary gland hamartoma

被引:61
作者
Bhathal, PS [1 ]
Hughes, NR [1 ]
Goodman, ZD [1 ]
机构
[1] ARMED FORCES INST PATHOL,DEPT HEPAT & GASTROINTESTINAL PATHOL,WASHINGTON,DC 20306
关键词
bile duct adenoma; peribiliary glands; hamartoma; cell phenotype; antigens D10 and 1F6; immunohistochemistry;
D O I
10.1097/00000478-199607000-00009
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The cell phenotype of so-called bile duct adenoma (BDA) was investigated immunohistochemically using monoclonal antibodies to two recently identified antigens (designated D10 and 1F6) extracted from human liver and cultured biliary epithelium. The acini and tubules of BDA consisted of serous and mucous cells that expressed D10 and 1F6. The intrahepatic peribiliary glands of normal liver, comprising intramural mucous glands and extramural tubuloalveolar seromucinous glands, similarly expressed D10 and 1F6 antigens. Antigen 1F6 was present in the cells forming the canals of Hering and normal bile ductules but not in interlobular and larger bile ducts. Proliferating bile ductules associated with large bile duct obstruction and alcoholic cirrhosis or the epithelia of the von Meyenberg complex and polycystic liver did not exhibit this combined profile of D10 and 1F6 expression and mucous cells, These findings suggest an origin of BDA from peribiliary glands rather than from bile ductules or ducts. Consistent with this view was our finding that 18 of the 30 BDA were spatially related to a large-calibre bile duct, Therefore, BDA, well known for its benign behavior, is a small mass of disorganized but mature peribiliary gland acini and tubules within a variable amount of stroma and should properly be called a peribiliary gland hamartoma.
引用
收藏
页码:858 / 864
页数:7
相关论文
共 21 条
[1]   BILE-DUCT ADENOMA - A STUDY OF 152 CASES [J].
ALLAIRE, GS ;
RABIN, L ;
ISHAK, KG ;
SESTERHENN, IA .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1988, 12 (09) :708-715
[2]  
BHATHAL PS, 1969, LAB INVEST, V20, P472
[3]   INCIDENCE OF ASSOCIATED DISEASES IN FAMILIAL POLYPOSIS-COLI [J].
BULOW, S .
SEMINARS IN SURGICAL ONCOLOGY, 1987, 3 (02) :84-87
[4]   BILE-DUCT PROLIFERATION - ITS TRUE SIGNIFICANCE [J].
BURT, AD ;
MACSWEEN, RNM .
HISTOPATHOLOGY, 1993, 23 (06) :599-602
[5]   ANTIGEN UNMASKING ON FORMALIN-FIXED, PARAFFIN-EMBEDDED TISSUE-SECTIONS [J].
CATTORETTI, G ;
PILERI, S ;
PARRAVICINI, C ;
BECKER, MHG ;
POGGI, S ;
BIFULCO, C ;
KEY, G ;
DAMATO, L ;
SABATTINI, E ;
FEUDALE, E ;
REYNOLDS, F ;
GERDES, J ;
RILKE, F .
JOURNAL OF PATHOLOGY, 1993, 171 (02) :83-98
[6]  
CHO C, 1978, ARCH SURG-CHICAGO, V113, P272
[7]  
Clara M., 1930, Z MIKR ANAT FORSCHG, V20, P584
[8]  
COOK HC, 1982, THEORY PRACTICE HIST, P180
[9]  
DHILLON AP, 1994, J PATHOL S, V173, pA184
[10]  
GOVINDARAJAN S, 1984, ARCH PATHOL LAB MED, V108, P922