Appetite suppression and weight loss after the cannabinoid antagonist SR141716

被引：413

作者：

Colombo, G

Agabio, R

Diaz, G

Lobina, C

Reali, R

Gessa, GL

机构：

[1] Univ Cagliari, Dept Neurosci, I-09124 Cagliari, Italy

[2] Univ Cagliari, Dept Cytomorphol, I-09124 Cagliari, Italy

[3] CNR, Ctr Neuropharmacol, Cagliari, Italy

来源：

LIFE SCIENCES | 1998年 / 63卷 / 08期

关键词：

brain cannabinoid receptor; SR141716; food intake; body weight;

D O I：

10.1016/S0024-3205(98)00322-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of the cannabinoid CB, receptor antagonist, SR 141716, on food intake and body weight was assessed in adult, non-obese Wistar rats. The daily administration of SR 141716 (2.5 and 10 mg/kg; i.p.) reduced dose-dependently both food intake and body weight. Tolerance to the anorectic effect developed within 5 days; in contrast, body weight in SR 141716-treated rats remained markedly below that of vehicle-treated rats throughout the entire treatment period (14 days). The results suggest that brain cannabinoid receptors are involved in the regulation of appetite and body weight. (C) 1998 Elsevier Science Inc.

引用

页码：PL113 / PL117

页数：5

共 13 条

[1] Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors [J].