Catalytic enantioselective synthesis of oxindoles and benzofuranones that bear a quaternary stereocenter

被引：235

作者：

Hills, ID ^{[1
]}

Fu, GC ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 33期

关键词：

asymmetric synthesis; heterocycles; homogeneous catalysis; ion pairs; rearrangements;

D O I：

10.1002/anie.200351666

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A common feature in indole- and benzofuran-derived natural products is a quaternary stereocenter in the 3-position of the heterocycle. The catalyst (-) -1 promotes the asymmetric synthesis of such compounds 3 (with up to 99% ee) through the rearrangement of O-acylated benzofuranones (X = O) and oxindoles (X = NR2) 2.

引用

页码：3921 / 3924

页数：4

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