Janus Kinase Antagonists and Other Novel Small Molecules for the Treatment of Crohn's Disease

被引：31

作者：

Boland, Brigid S. ^{[1
]}

Vermeire, Severine ^{[2
]}

机构：

[1] Univ Calif San Diego, Ctr Inflammatory Bowel Dis, ACTRI, Div Gastroenterol,Dept Med, 9452 Med Ctr Dr, La Jolla, CA 92093 USA

[2] Univ Hosp Leuven, Dept Gastroenterol, Herestr 49, B-3000 Leuven, Belgium

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2017年 / 46卷 / 03期

关键词：

Crohn's disease; Jak inhibitor; Filgotinib; TGF-beta; SMAD7; Mongersen; Sphingosine-1-phosphate receptor; Ozanimod; PLACEBO-CONTROLLED TRIAL; ANTISENSE OLIGONUCLEOTIDE; MAINTENANCE THERAPY; RHEUMATOID-ARTHRITIS; SELECTIVE INHIBITOR; INDUCTION THERAPY; HERPES-ZOSTER; TOFACITINIB; BETA; SMAD7;

D O I：

10.1016/j.gtc.2017.05.015

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

There is an ongoing, unmet need for effective therapies for Crohn's disease. Treatments for Crohn's disease continue to evolve from the traditional biologics to novel small molecules, with targeted mechanisms directed toward pathways that are dysregulated in Crohn's disease. There are multiple emerging mechanisms of action, including Janus kinase inhibition, Smad7 inhibition, and sphingosine-1-phosphate receptor modulators, that are administered as oral medications, and small molecules represent the next generation of therapies for Crohn's disease.

引用

页码：627 / +

页数：19

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