Healthcare-associated outbreaks and community-acquired infections due to MRSA carrying the Panton-Valentine leucocidin gene in southeastern Germany

被引:89
作者
Linde, H
Wagenlehner, F
Strommenger, B
Drubel, I
Tanzer, J
Reischl, U
Raab, U
Höller, C
Naber, KG
Witte, W
Hanses, F
Salzberger, B
Lehn, N
机构
[1] Inst Med Mikrobiol & Hyg, D-93049 Regensburg, Germany
[2] Klinikum St Elisabeth, Urol Klin, D-94315 Straubing, Germany
[3] Robert Koch Inst, Natl Referenzzentrum Staphylokokken, D-38843 Wernigerode, Germany
[4] Klinikum Furth, Hyg Abt, D-90766 Furth, Germany
[5] Seniorenheim St Nikloa, D-94315 Straubing, Germany
[6] Bayer Landesamt Gesundheit & Lebensmittelsicherhe, D-85764 Oberschleissheim, Germany
[7] Univ Klinikum Regensburg, Innere Med Abt 1, D-93049 Regensburg, Germany
关键词
D O I
10.1007/s10096-005-1341-7
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
In response to several isolations of methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leucocidin gene (PVL-MRSA), the present study was conducted to document the spread of infection in a small region of southeastern Germany. During a 9-month period, two healthcare-associated outbreaks with PVL-MRSA occurred, affecting 83 patients, personnel and contacts of personnel, and 34 additional cases were detected in the community. The clinical spectrum ranged from colonization to skin infection and necrotizing pneumonia. The findings represent the largest number of PVL-MRSA cases detected in Germany so far, and demonstrate the potential of this emerging pathogen to spread within the community and in healthcare institutions.
引用
收藏
页码:419 / 422
页数:4
相关论文
共 14 条
[1]   Genome and virulence determinants of high virulence community-acquired MRSA [J].
Baba, T ;
Takeuchi, F ;
Kuroda, M ;
Yuzawa, H ;
Aoki, K ;
Oguchi, A ;
Nagai, Y ;
Iwama, N ;
Asano, K ;
Naimi, T ;
Kuroda, H ;
Cui, L ;
Yamamoto, K ;
Hiramatsu, K .
LANCET, 2002, 359 (9320) :1819-1827
[2]   Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia [J].
Lina, G ;
Piémont, Y ;
Godail-Gamot, F ;
Bes, M ;
Peter, MO ;
Gauduchon, V ;
Vandenesch, F ;
Etienne, J .
CLINICAL INFECTIOUS DISEASES, 1999, 29 (05) :1128-1132
[3]   Novel type of staphylococcal cassette chromosome mec identified in community-acquired methicillin-resistant Staphylococcus aureus strains [J].
Ma, XX ;
Ito, T ;
Tiensasitorn, C ;
Jamklang, M ;
Chongtrakool, P ;
Boyle-Vavra, S ;
Daum, RS ;
Hiramatsu, K .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (04) :1147-1152
[4]  
National Committee for Clinical Laboratory Standards, 1999, M100S9 NCCLS
[5]   Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community [J].
Okuma, K ;
Iwakawa, K ;
Turnidge, JD ;
Grubb, WB ;
Bell, JM ;
O'Brien, FG ;
Coombs, GW ;
Pearman, JW ;
Tenover, FC ;
Kapi, M ;
Tiensasitorn, C ;
Ito, T ;
Hiramatsu, K .
JOURNAL OF CLINICAL MICROBIOLOGY, 2002, 40 (11) :4289-4294
[6]  
Reischl U, 2000, J CLIN MICROBIOL, V38, P2429
[7]   Multilocus sequence typing and the evolution of methicillin-resistant Staphylococcus aureus [J].
Robinson, DA ;
Enright, MC .
CLINICAL MICROBIOLOGY AND INFECTION, 2004, 10 (02) :92-97
[8]   Hospital transmission of community-acquired methicillin-resistant Staphylococcus aureus among postpartum women [J].
Saiman, L ;
O'Keefe, M ;
Graham, PL ;
Wu, F ;
Saïd-Salim, B ;
Kreiswirth, B ;
LaSala, A ;
Schlievert, PM ;
Della-Latta, P .
CLINICAL INFECTIOUS DISEASES, 2003, 37 (10) :1313-1319
[9]   Community-acquired methicillin-resistant Staphylococcus aureus:: A meta-analysis of prevalence and risk factors [J].
Salgado, CD ;
Farr, BM ;
Calfee, DP .
CLINICAL INFECTIOUS DISEASES, 2003, 36 (02) :131-139
[10]   Correlation of MIC methods and tentative interpretive criteria for disk diffusion susceptibility testing using NCCLS methodology for fusidic acid [J].
Skov, R ;
Frimodt-Moller, N ;
Espersen, F .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2001, 40 (03) :111-116