Cytotoxic constituents of Isodon rubescens var. lushiensis

被引：36

作者：

Han, QB

Zhao, AH

Zhang, JX

Lu, Y

Zhang, LL

Zheng, QT

Sun, HD ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

[2] Xinxiang Med Coll, Dept Chem, Xining 453000, Peoples R China

[3] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 10期

关键词：

D O I：

10.1021/np030165w

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new ent-kaurane diterpenoids, ludongnins F-J (1-5), along with 10 known compounds, guidongnins A-C (6-8), angustifolin (9), 6-epiangustifolin (10), sculponeatin J (11), gardenin D, 5,3',4'-trihydroxy-6,7,8-trimethoxyflavone, pedalitin, and quercetin, were isolated from the leaves of Isodon rubescens var. lushiensis. The structures of 1-5 were determined by spectroscopic analysis, as well as X-ray crystallographic analysis of 1. Compounds 1-11 were evaluated against K562 leukemia cells for their cytotoxic effects.

引用

页码：1391 / 1394

页数：4

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