Signal transduction - New exchange, new target

被引：32

作者：

Downward, J ^{[1
]}

机构：

[1] Imperial Canc Res Fund, Signal Transduct Lab, London WC2A 3PX, England

来源：

NATURE | 1998年 / 396卷 / 6710期

关键词：

D O I：

10.1038/24743

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The many members of the Ras superfamily of small guanine-nucleotide-binding (G) proteins are thought to be regulated in a broadly similar way. However, a study of the proteins that regulate one member, Rap1, shows that this regulation may be much more varied than previously thought. Not only that, but these studies have unearthed another class of direct target proteins for the second messenger cyclic AMP.

引用

页码：416 / 417

页数：2

共 11 条

[1] CYCLIC-AMP-DEPENDENT ACTIVATION OF RAP1B
ALTSCHULER, DL
PETERSON, SN
OSTROWSKI, MC
LAPETINA, EG
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (18) : 10373 - 10376
[2] All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral
Bos, JL
[J]. EMBO JOURNAL, 1998, 17 (23) : 6776 - 6782
[3] Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
de Rooij, J
Zwartkruis, FJT
Verheijen, MHG
Cool, RH
Nijman, SMB
Wittinghofer, A
Bos, JL
[J]. NATURE, 1998, 396 (6710) : 474 - 477
[4] RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs
Ebinu, JO
Bottorff, DA
Chan, EYW
Stang, SL
Dunn, RJ
Stone, JC
[J]. SCIENCE, 1998, 280 (5366) : 1082 - 1086
[5] CALCIUM ACTIVATION OF RAS MEDIATED BY NEURONAL EXCHANGE FACTOR RAS-GRF
FARNSWORTH, CL
FRESHNEY, NW
ROSEN, LB
GHOSH, A
GREENBERG, ME
FEIG, LA
[J]. NATURE, 1995, 376 (6540) : 524 - 527
[6] Rapid Ca2+-mediated activation of Rap1 in human platelets
Franke, B
Akkerman, JWN
Bos, JL
[J]. EMBO JOURNAL, 1997, 16 (02) : 252 - 259
[7] A RAS-RELATED GENE WITH TRANSFORMATION SUPPRESSOR ACTIVITY
KITAYAMA, H
SUGIMOTO, Y
MATSUZAKI, T
IKAWA, Y
NODA, M
[J]. CELL, 1989, 56 (01) : 77 - 84
[8] Phosphorylation-dependent activation of the Ras-GRF/CDC25(Mm) exchange factor by muscarinic receptors and G-protein beta gamma subunits
Mattingly, RR
Macara, IG
[J]. NATURE, 1996, 382 (6588) : 268 - 272
[9] SIGNAL TRANSDUCTION - HOW RECEPTORS TURN RAS ON
MCCORMICK, F
[J]. NATURE, 1993, 363 (6424) : 15 - 16
[10] Rap1 mediates sustained MAP kinase activation induced by nerve growth factor
York, RD
Yao, H
Dillon, T
Ellig, CL
Eckert, SP
McCleskey, EW
Stork, PJS
[J]. NATURE, 1998, 392 (6676) : 622 - 626

← 1 2 →