Endogenous opioid peptides, endomorphin-1 and -2 and deltorphin I, stimulate angiogenesis in the CAM assay

被引：22

作者：

Dai, Xu ^{[1
,2
,3
]}

Cui, Shi-gang ^{[1
,2
,3
]}

Wang, Ting ^{[1
,2
,3
]}

Liu, Qian ^{[2
,3
]}

Song, Hong-Jin ^{[2
,3
]}

Wang, Rui ^{[1
,2
,3
]}

机构：

[1] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, State Key Lab Chinese Med & Mol Pharmacol, Kowloon, Hong Kong, Peoples R China

[2] Lanzhou Univ, Sch Life Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China

[3] Lanzhou Univ, Sch Life Sci, Inst Biochem & Mol Biol, Lanzhou 730000, Peoples R China

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2008年 / 579卷 / 1-3期

关键词：

endomorphin-1; endomorphin-2; deltorphin; 1; angiogenesis; CAM;

D O I：

10.1016/j.ejphar.2007.10.015

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The opioid peptides modulate extensive bioactivities, including pain, cardiovascular response, development and so on. The effects of endogenous opioid peptides on angiogenesis were evaluated in the chick embryo chorioallantoic membrane (CAM) assay for the first time in the present study. Endomorphin-1, endomorphin-2 and deltorphin I at the dosage of 1, 10, 100 nmol/embryo could stimulate angiogenesis dose-dependently, respectively. Naloxone, the nonselective opioid receptor antagonist, did not influence angiogenesis alone; but it could antagonize the stimulative effects of the opioid peptides on angiogenesis when it was administrated in combination with the opioid peptides. Taken altogether, the results suggested that endogenous opioid peptides (endomorpbin-1 and -2 and deltorphin 1) stimulated angiogenesis in the CAM assay, and these effects were modulated with the opioid receptors. These data are important for potential future clinical implementation. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：269 / 275

页数：7

共 70 条

[1] ANGIOGENESIS INHIBITION - A REVIEW [J].