Nuclear receptor ligands: Rational and effective therapy for chronic cholestatic liver disease?

被引:66
作者
Boyer, JL [1 ]
机构
[1] Yale Univ, Sch Med, Dept Med, Ctr Liver, New Haven, CT 06520 USA
关键词
D O I
10.1053/j.gastro.2005.06.053
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
引用
收藏
页码:735 / 740
页数:6
相关论文
共 33 条
[1]   Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice [J].
Assem, M ;
Schuetz, EG ;
Leggas, M ;
Sun, DX ;
Yasuda, K ;
Reid, G ;
Zelcer, N ;
Adachi, M ;
Strom, S ;
Evans, RM ;
Moore, DD ;
Borst, P ;
Schuetz, JD .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (21) :22250-22257
[2]  
BACHS L, 1989, LANCET, V1, P574
[3]   PHENOBARBITAL EFFECTS IN CHOLESTATIC LIVER-DISEASE [J].
BLOOMER, JR ;
BOYER, JL .
ANNALS OF INTERNAL MEDICINE, 1975, 82 (03) :310-317
[4]   Unexpected clinical remission of cholestasis after rifampicin therapy in patients with normal or slightly increased levels of γ-glutamyl transpeptidase [J].
Cançado, ELR ;
Leitao, RMC ;
Carrilho, FJ ;
Laudanna, AA .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 1998, 93 (09) :1510-1517
[5]   Nuclear receptors and lipid physiology: Opening the X-files [J].
Chawla, A ;
Repa, JJ ;
Evans, RM ;
Mangelsdorf, DJ .
SCIENCE, 2001, 294 (5548) :1866-1870
[6]   Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms [J].
Chiang, JYL .
JOURNAL OF HEPATOLOGY, 2004, 40 (03) :539-551
[7]   Bile acid regulation of hepatic physiology - III. Bile acids and nuclear receptors [J].
Chiang, JYL .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2003, 284 (03) :G349-G356
[8]   No relevant effect of ursodeoxycholic acid on cytochrome P450 3A metabolism in primary biliary cirrhosis [J].
Dilger, K ;
Denk, A ;
Heeg, MHJ ;
Beuers, U .
HEPATOLOGY, 2005, 41 (03) :595-602
[9]   Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism [J].
Eloranta, JJ ;
Kullak-Ublick, GA .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2005, 433 (02) :397-412
[10]   Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis [J].
Fiorucci, S ;
Clerici, C ;
Antonelli, E ;
Orlandi, S ;
Goodwin, B ;
Sadeghpour, BM ;
Sabatino, G ;
Russo, G ;
Castellani, D ;
Willson, TM ;
Pruzanski, M ;
Pellicciari, R ;
Morelli, A .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2005, 313 (02) :604-612