Identification of plexin family molecules in mice

被引：41

作者：

Kameyama, T ^{[1
]}

Murakami, Y ^{[1
]}

Suto, F ^{[1
]}

Kawakami, A ^{[1
]}

Takagi, S ^{[1
]}

Hirata, T ^{[1
]}

Fujisawa, H ^{[1
]}

机构：

[1] NAGOYA UNIV,GRAD SCH SCI,DIV BIOL SCI,DEV BIOL LAB,GRP DEV NEUROBIOL,CHIKUSA KU,NAGOYA,AICHI 46401,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 226卷 / 02期

基金：

日本科学技术振兴机构; 日本学术振兴会;

关键词：

D O I：

10.1006/bbrc.1996.1367

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

By screening of E17.5 mouse brain cDNA libraries, we isolated two cDNAs encoding new plexin-like proteins. Sequencing revealed that these two proteins were type 1 membrane proteins which showed over 60% identity at the amino acid level to mouse plexin 1. Moreover, putative extracellular segments of these two proteins had three repeats of a cysteine-rich domain which is a common motif for plexin proteins. Thus, we named these two proteins mouse plexin 2 and mouse plexin 3. We obtained mouse plexin 3 cDNA clones in which a part of protein-coding region was deleted. Also, Northern blot analysis showed molecular heterogeneity in mouse plexin 2 mRNAs. These findings indicate that, in the mouse, plexins comprise a molecular family (the plexin family). (C) 1996 Academic Press, Inc.

引用

页码：396 / 402

页数：7

共 14 条

[1]

IDENTIFICATION OF THE HEPATOCYTE GROWTH-FACTOR RECEPTOR AS THE C-MET PROTOONCOGENE PRODUCT [J].