Molecular Details of the Recognition of Blood Group Antigens by a Human Norovirus as Determined by STD NMR Spectroscopy

被引：54

作者：

Fiege, Brigitte ^{[1
]}

Rademacher, Christoph ^{[1
]}

Cartmell, Jonathan ^{[2
]}

Kitov, Pavel I. ^{[2
]}

Parra, Francisco ^{[3
]}

Peters, Thomas ^{[1
]}

机构：

[1] Univ Lubeck, Inst Chem, Ctr Struct & Cell Biol Med, D-23562 Lubeck, Germany

[2] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada

[3] Univ Oviedo, Inst Univ Biotecnol Asturias, Dept Bioquim & Biol Mol, E-33006 Oviedo, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 04期

关键词：

bioactive conformations; blood group antigens; sialyl Lewisx; NMR spectroscopy; TRANSFER DIFFERENCE NMR; VIRUS-LIKE PARTICLES; SIALYL LEWIS(X); LIGAND-BINDING; E-SELECTIN; PROTEIN; CONFORMATION; RECEPTOR; SACCHARIDES; SPECIFICITY;

D O I：

10.1002/anie.201105719

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tracing the infection: The binding of human norovirus particles to blood group antigens was investigated using NMR spectroscopy. Binding epitopes were determined at atomic resolution, information on the binding specificity was obtained, and the bioactive conformation of various sugars was revealed. This provides valuable information for the design of entry inhibitors against this important class of human pathogenic viruses. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：928 / 932

页数：5

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