Integrins and cancer

被引：453

作者：

Varner, JA ^{[1
]}

Cheresh, DA ^{[1
]}

机构：

[1] Scripps Res Inst, DEPT IMMUNOL, LA JOLLA, CA 92037 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1996年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0955-0674(96)80115-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The past year or two has seen great advances in the elucidation of significant roles for integrins in cancer cells. These include roles in signal transduction, gene expression, proliferation, apoptosis regulation, invasion and metastasis, and angiogenesis. In particular, integrin alpha nu beta 3 has been implicated in the neovascularization of tumors. In addition, this integrin has been shown to contribute to the survival, proliferation and metastatic phenotype of human melanoma.

引用

页码：724 / 730

页数：7

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