Role of mesoporous silicates on carbamazepine dissolution rate enhancement

被引：65

作者：

Ambrogi, Valeria ^{[1
]}

Perioli, Luana ^{[1
]}

Marmottini, Fabio ^{[2
]}

Accorsi, Oriana ^{[1
]}

Pagano, Cinzia ^{[1
]}

Ricci, Maurizio ^{[1
]}

Rossi, Carlo ^{[1
]}

机构：

[1] Univ Perugia, Dipartimento Chim & Tecnol Farmaco, I-06123 Perugia, Italy

[2] Univ Perugia, Dipartimento Ingn Civil & Ambientale, I-06125 Perugia, Italy

来源：

MICROPOROUS AND MESOPOROUS MATERIALS | 2008年 / 113卷 / 1-3期

关键词：

mesoporous silicates; poorly water solubility drug; carbamazepine; dissolution rate; physical stability;

D O I：

10.1016/j.micromeso.2007.12.003

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Carbamazepine is an antiepileptic drug characterized by poorly water solubility that affects negatively its bioavailability. Here we report oil the ability of the mesoporous silicate MCM-41 to act as a vehicle able to improve the drug dissolution rate by preventing drug crystallization. Carbamazepine was adsorbed into nanopores of MCM-41 and the drug, loaded MCM-41 was characterized by X-ray powder diffraction, N-2 adsorption, FT-IR spectroscopy and thermogravimetric and differential scanning calorimetry analyses. Carbamazepine loading resulted 14% and the drug was not arranged in crystalline form. In vitro drug release results showed a remarkable increase of carbamazepine dissolution rate in all the different tested media. As this improvement is due both to the high specific surface area of loaded MCM-41 and to the lack of crystalline drug, storage stability studies at different environment conditions were conducted in order to investigate the ability of MCM-41 to prevent drug crystallization. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：445 / 452

页数：8

共 30 条

[1] Improvement of dissolution rate of piroxicam by inclusion into MCM-41 mesoporous silicate [J].