Increased fluoroquinolone resistance with time in Escherichia coli from > 17,000 patients at a large county hospital as a function of culture site, age, sex, and location

被引:59
作者
Boyd, Lauren Becnel [1 ]
Atmar, Robert L. [1 ,2 ]
Randall, Graham L. [3 ]
Hamill, Richard J. [1 ,2 ,5 ]
Steffen, David [4 ]
Zechiedrich, Lynn [1 ,3 ]
机构
[1] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Med, Houston, TX 77030 USA
[3] Baylor Coll Med, Interinstitut Program Struct & Computat Biol & Mo, Houston, TX 77030 USA
[4] Baylor Coll Med, Bioinformat Resource Ctr, Houston, TX 77030 USA
[5] Michael E Debakey Vet Adm Med Ctr, Houston, TX 77030 USA
关键词
D O I
10.1186/1471-2334-8-4
中图分类号
R51 [传染病];
学科分类号
100401 [流行病与卫生统计学];
摘要
Background: Escherichia coli infections are common and often treated with fluoroquinolones. Fluoroquinolone resistance is of worldwide importance and is monitored by national and international surveillance networks. In this study, we analyzed the effects of time, culture site, and patient age, sex, and location on fluoroquinolone resistance in E. coli clinical isolates. Methods: To understand how patient factors and time influenced fluoroquinolone resistance and to determine how well data from surveillance networks predict trends at Ben Taub General Hospital in Houston, TX, we used Perl to parse and MySQL to house data from antibiograms (n congruent to 21,000) for E. coli isolated between 1999 to 2004 using Chi Square, Bonferroni, and Multiple Linear Regression methods. Results: Fluoroquinolone resistance (i) increased with time; (ii) exceeded national averages by 2- to 4- fold; (iii) was higher in males than females, largely because of urinary isolates from male outpatients; (iv) increased with patient age; (v) was 3% in pediatric patients; (vi) was higher in hospitalized patients than outpatients; (vii) was higher in sputum samples, particularly from inpatients, than all other culture sites, including blood and urine, regardless of patient location; and (viii) was lowest in genital isolates than all other culture sites. Additionally, the data suggest that, with regard to susceptibility or resistance by the Dade Behring MicroScan system, a single fluoroquinolone suffices as a "surrogate marker" for all of the fluoroquinolone tested. Conclusion: Large surveillance programs often did not predict E. coli fluoroquinolone resistance trends at a large, urban hospital with a largely indigent, ethnically diverse patient population or its affiliated community clinics.
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