TGR5: A Novel Target for Weight Maintenance and Glucose Metabolism

被引：95

作者：

Chen, Xiaosong ^{[1
,2
]}

Lou, Guiyu ^{[1
,3
]}

Meng, Zhipeng ^{[1
]}

Huang, Wendong ^{[1
]}

机构：

[1] City Hope Natl Med Ctr, Div Gene Regulat & Drug Discovery, Beckman Res Inst, Duarte, CA 91010 USA

[2] Fujian Med Univ, Dept Plast Surg, Union Hosp, Fuzhou 350001, Fujian, Peoples R China

[3] Third Mil Med Univ, Dept Biochem & Mol Biol, Chongqing 400038, Peoples R China

来源：

EXPERIMENTAL DIABETES RESEARCH | 2011年

关键词：

BILE-ACID RECEPTOR; FARNESOID-X-RECEPTOR; BROWN ADIPOSE-TISSUE; NUCLEAR RECEPTOR; INTERNATIONAL-UNION; ENERGY-EXPENDITURE; IDENTIFICATION; MICE; FXR; LIGANDS;

D O I：

10.1155/2011/853501

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

TGR5, an emerging G protein-coupled receptor, was identified as a membrane receptor for bile acids. The expression of TGR5 and its function are distinct from the previously identified nuclear bile acid receptor, farnesoid X receptor (FXR). These two bile acid receptors complement with each other for maintaining bile acid homeostasis and mediating bile acid signaling. Both receptors are also shown to play roles in regulating inflammation and glucose metabolism. An interesting finding for TGR5 is its role in energy metabolism. The discovery of TGR5 expression in brown adipocyte tissues (BATs) and the recent demonstration of BAT in adult human body suggest a potential approach to combat obesity by targeting TGR5 to increase thermogenesis. We summarize here the latest finding of TGR5 research, especially its role in energy metabolism and glucose homeostasis.

引用

页数：5

共 52 条

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