Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity

被引：628

作者：

Gainetdinov, RR

Wetsel, WC

Jones, SR

Levin, ED

Jaber, M

Caron, MG ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Cell Biol, Howard Hughes Med Inst, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[3] Duke Univ, Med Ctr, Dept Psychiat, Durham, NC 27710 USA

[4] Duke Univ, Med Ctr, Dept Med Endocrinol, Durham, NC 27710 USA

来源：

SCIENCE | 1999年 / 283卷 / 5400期

关键词：

D O I：

10.1126/science.283.5400.397

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mechanism by which psychostimulants act as calming agents in humans with attention-deficit hyperactivity disorder (ADHD) or hyperkinetic disorder is currently unknown. Mice Lacking the gene encoding the plasma membrane dopamine transporter (DAT) have elevated dopaminergic tone and are hyperactive. This activity was exacerbated by exposure to a novel environment. Additionally, these mice were impaired in spatial cognitive fund:ion, and they showed a decrease in locomotion in response to psychostimulants. This paradoxical calming effect of psychostimulants depended on serotonergic neurotransmission. The parallels between the DAT knockout mice and individuals with ADHD suggest that common mechanisms may underlie some of their behaviors and responses to psychostimulants.

引用

页码：397 / 401

页数：5

共 71 条

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