Bilateral splanchnicotomy does not affect lipopolysaccharide-induced fever in rats

被引：12

作者：

Dogan, MD

Kulchitsky, VA

Patel, S

Pétervári, E

Székely, M

Romanovsky, AA

机构：

[1] St Josephs Hosp, Systemic Inflammat Lab, Phoenix, AZ 85013 USA

[2] Univ Pecs, Fac Med, Dept Pathophysiol, H-7624 Pecs, Hungary

来源：

BRAIN RESEARCH | 2003年 / 993卷 / 1-2期

关键词：

febrile response; thermnoregulation; splanchnic nerve; vagus nerve; capsaicin;

D O I：

10.1016/j.brainres.2003.09.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intraperitoneal capsaicin desensitizes sensory fibers traveling within both the vagus and splanchnic nerves. Because capsaicin desensitization blocks the first phase of lipopolysaccharide (LPS) fever, whereas surgical vagotomy does not, splanchnic mediation of the first phase was proposed. However, all phases of the febrile response of splanchnicotomized rats to intravenous LPS (10 mug/kg) were similar to those of sham-operated controls. Hence, the splanchnic nerve is likely uninvolved in LPS fever. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：227 / 229

页数：3

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