Dendritic cells and cytokines in immune rejection of cancer

被引：47

作者：

Ferrantini, Maria ^{[1
]}

Capone, Imerio ^{[1
]}

Belardelli, Filippo ^{[1
]}

机构：

[1] Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2008年 / 19卷 / 01期

关键词：

dendritic cells; cytokines; immune potentiators; cancer immunity; immunotherapy;

D O I：

10.1016/j.cytogfr.2007.10.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dendritic cells (DCs) play a crucial role in linking innate and adaptive immunity and, thus, in the generation of a protective immune response against both infectious diseases and tumors. The ability of DCs to prime and expand an immune response is regulated by signals acting through soluble mediators, mainly cytokines and chemokines. Understanding how cytokines influence DC functions and orchestrate the interactions of DCs with other immune cells is strictly instrumental to the progress in cancer immunotherapy. Herein, we will illustrate how certain cytokines and immune stimulating molecules can induce and sustain the antitumor immune response by acting on DCs. We will also discuss these cytokine-DC interactions in the light of clinical results in cancer patients. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：93 / 107

页数：15

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