The pharmacokinetics and interactions of ivermectin in humans -: A mini-review

被引：271

作者：

Canga, Aranzazu Gonzalez ^{[1
]}

Prieto, Ana M. Sahagun ^{[1
]}

Liebana, M. Jose Diez ^{[1
]}

Martinez, Nelida Fernandez ^{[1
]}

Vega, Matilde Sierra ^{[1
]}

Vieitez, Juan J. Garcia ^{[1
]}

机构：

[1] Univ Leon, Fac Vet, Dept Biomed Sci, E-24071 Leon, Spain

来源：

AAPS JOURNAL | 2008年 / 10卷 / 01期

关键词：

humans; interactions; ivermectin; pharmacokinetics;

D O I：

10.1208/s12248-007-9000-9

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Ivermectin is an antiparasitic drug with a broad spectrum of activity, high efficacy as well as a wide margin of safety. Since 1987, this compound has a widespread use in veterinary medicine and it use has been extended in humans. Here we present a brief review of the information availabile regarding the pharmacokinetics and interactions of ivermectin in humans. Awareness of these characteristics could improve the clinical efficacy of Ivermectin. All Authors declare that they do not have any Conflict of interest and that the work is original. All Authors agree that the contents of the manuscript are confidential and will not be copyrighted, submitted, or published elsewhere (including the Internet), in any language, while acceptance by the Journal is under consideration.

引用

页码：42 / 46

页数：5

共 36 条

[1]

Awadzi K, 1995, TROP MED PARASITOL, V46, P213

[2]

The safety, tolerability and pharmacokinetics of levamisole alone, levamisole plus ivermectin, and levamisole plus albendazole, and their efficacy against Onchocerca volvulus [J].

Awadzi, K ;

Edwards, G ;

Opoku, NO ;

Ardrey, AE ;

Favager, S ;

Addy, ET ;

Attah, SK ;

Yamuah, LK ;

Quartey, BT .

ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 2004, 98 (06) :595-614

[3]

The co-administration of ivermectin and albendazole safety, pharmacokinetics and efficacy against Onchocerca volvulus [J].

Awadzi, K ;

Edwards, G ;

Duke, BOL ;

Opoku, NO ;

Attah, SK ;

Addy, ET ;

Ardrey, AE ;

Quartey, BT .

ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 2003, 97 (02) :165-178

[4]

AWADZI K, 1994, TROP MED PARASITOL, V45, P203

[5]

Awadzi K, 1997, ANN TROP MED PARASIT, V91, P281, DOI 10.1080/00034989761139

[6]

Ivermectin distribution in the plasma and tissues of patients infected with Onchocerca volvulus [J].

Baraka, OZ ;

Mahmoud, BM ;

Marschke, CK ;

Geary, TG ;

Homeida, MMA ;

Williams, JF .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1996, 50 (05) :407-410

[7]

Cross HF, 1997, ANN TROP MED PARASIT, V91, P393, DOI 10.1080/00034989761012

[8]

Ivermectin: pharmacology and application in dermatology [J].

Dourmishev, AL ;

Dourmishev, LA ;

Schwartz, RA .

INTERNATIONAL JOURNAL OF DERMATOLOGY, 2005, 44 (12) :981-988

[9]

THE RELATIVE SYSTEMIC AVAILABILITY OF INVERMECTIN AFTER ADMINISTRATION AS CAPSULE, TABLET, AND ORAL SOLUTION [J].

EDWARDS, G ;

DINGSDALE, A ;

HELSBY, N ;

ORME, MLE ;

BRECKENRIDGE, AM .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1988, 35 (06) :681-684

[10]

ELKASSABY MH, 1991, TROP MED PARASITOL, V42, P79

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