p300 regulates p63 transcriptional activity

被引：42

作者：

MacPartlin, M

Zeng, S

Lee, H

Stauffer, D

Jin, YT

Thayer, M

Lu, H

机构：

[1] OR Hlth & Sci Univ, Dept Biochem & Mol Biol, Portland, OR 97239 USA

[2] OR Hlth & Sci Univ, Div Mol Med, Dept Med, Portland, OR 97239 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2005年 / 280卷 / 34期

关键词：

D O I：

10.1074/jbc.M503352200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transcriptional co-activator p300 has been reported to regulate the tumor suppressor p53 and its ortholog p73. Here we describe a study showing that this coactivator also regulates the transcriptional function of p63. p300 bound to the N-terminal domain of p63 gamma, and p63 gamma bound to the N terminus of p300 in vitro and in cells. p300, but not its acetylase-defective mutant AT2, stimulated p63 gamma-dependent transcription and induction of p21 in cells, consequently leading to G(1) arrest. Inversely, the Delta N-p63 gamma isoform as well as p300AT2 inhibited the induction of p21 by p63 gamma. These results suggest that p300 regulates p63-dependent transcription of p21.

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页码：30604 / 30610

页数：7

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