Efficient catalytic enantioselective Mannich-type reactions using a zirconium-bis(binaphthol)methane complex

被引：56

作者：

Ishitani, H

Kitazawa, T

Kobayashi, S

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, CREST, Japan Sci & Technol Corp,Bunkyo Ku, Tokyo 1130033, Japan

[2] Sci Univ Tokyo, Fac Sci, Dept Appl Chem, Shinjuku Ku, Tokyo 1620825, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 11期

关键词：

D O I：

10.1016/S0040-4039(99)00138-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the presence of a catalytic amount of a zirconium-bis(binaphthol)methane complex (5), Mannich-type reactions of aldimines with silyl enolates proceeded smoothly to afford the corresponding adducts in high yields with high enantiomeric excesses. (R)-(R)-Bis(3-BINOL)methane 6, that was prepared by linking two binaphthols, was shown to be very effective in these reactions. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2161 / 2164

页数：4

共 8 条

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