Effect of fast duration on disposition of an intraduodenal glucose load in the conscious dog

被引:24
作者
Galassetti, P
Hamilton, KS
Gibbons, FK
Bracy, DP
Lacy, DB
Cherrington, AD
Wasserman, DH
机构
[1] Vanderbilt Univ, Med Ctr, Sch Med, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Sch Med, Ctr Diabet Res & Training, Nashville, TN 37232 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 1999年 / 276卷 / 03期
关键词
fasting; glycogen; glucose uptake; gut; liver; skeletal muscle;
D O I
10.1152/ajpendo.1999.276.3.E543
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The effects of prior fast duration (18 h, n = 8; 42 h, n = 8) on the glycemic and tissue-specific responses to an intraduodenal glucose load were studied in chronically catheterized conscious dogs. [3-H-3]glucose was infused throughout the study. After basal measurements, glucose spiked with [U-C-14]glucose was infused for 150 min intraduodenally. Arterial insulin and glucagon were similar in the two groups. Arterial glucose (mg/dl) rose similar to 70% more during glucose infusion after 42 h than after an 18-h fast. The net hepatic glucose balance (mg kg(-1) min-l) was similar in the two groups (basal: 1.8 +/- 0.2 and 2.0 +/- 0.3; glucose infusion: -2.2 +/- 0.5 and -2.2 +/- 0.7). The intrahepatic fate of glucose was 79% glycogen, 13% oxidized, and 8% lactate release after a 42-h fast; it was 23% glycogen, 21% oxidized, and 56% lactate release after an 18-h fast. Net hindlimb glucose uptake was similar between groups. The appearance of intraduodenal glucose during glucose infusion (mg/kg) was 900 +/- 50 and 1,120 +/- 40 after 18- and 42-h fasts (P < 0.01). Conclusion: glucose administration after prolonged fasting induces higher circulating glucose than a shorter fast (increased appearance of intraduodenal glucose); Liver and hindlimb glucose uptakes and the hormonal response, however, are unchanged; finally, an intrahepatic redistribution of carbons favors glycogen deposition.
引用
收藏
页码:E543 / E552
页数:10
相关论文
共 30 条
[1]   GLYCOGEN TURNOVER DURING REFEEDING IN THE POSTABSORPTIVE DOG - IMPLICATIONS FOR THE ESTIMATION OF GLYCOGEN FORMATION USING TRACER METHODS [J].
BARRETT, EJ ;
BEVILACQUA, S ;
DEFRONZO, RA ;
FERRANNINI, E .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1994, 43 (03) :285-292
[2]  
Bird AR, 1996, J ANIM SCI, V74, P2523
[3]  
CHAN T, 1976, ANN BIOCH, V77, P96
[4]  
COPPACK SW, 1994, J LIPID RES, V35, P177
[5]   GLUCOREGULATORY RESPONSES IN NORMAL AND DIABETIC DOGS RECORDED BY A NEW TRACER METHOD [J].
COWAN, JS ;
HETENYI, G .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1971, 20 (04) :360-+
[6]   SIMULTANEOUS SYNTHESIS AND DEGRADATION OF RAT-LIVER GLYCOGEN - AN INVIVO NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPIC STUDY [J].
DAVID, M ;
PETIT, WA ;
LAUGHLIN, MR ;
SHULMAN, RG ;
KING, JE ;
BARRETT, EJ .
JOURNAL OF CLINICAL INVESTIGATION, 1990, 86 (02) :612-617
[7]   EFFECT OF A MIXED MEAL ON HEPATIC LACTATE AND GLUCONEOGENIC PRECURSOR METABOLISM IN DOGS [J].
DAVIS, MA ;
WILLIAMS, PE ;
CHERRINGTON, AD .
AMERICAN JOURNAL OF PHYSIOLOGY, 1984, 247 (03) :E362-E369
[8]  
DEBODO RC, 1963, RECENT PROG HORM RES, V19, P445
[9]   EFFECT OF A 3-DAY FAST ON GLUCOSE STORAGE AND OXIDATION IN OBESE HYPERINSULINEMIC DIABETICS [J].
FELBER, JP ;
MEYER, HU ;
CURCHOD, B ;
MAEDER, E ;
PAHUD, P ;
JEQUIER, E .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1981, 30 (02) :184-189
[10]   MECHANISMS OF STARVATION DIABETES - A STUDY WITH DOUBLE TRACER AND INDIRECT CALORIMETRY [J].
FERY, F ;
DATTELLIS, NP ;
BALASSE, EO .
AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (06) :E770-E777