Cerebral neurons express interleukin-6 after transient forebrain ischemia in gerbils

被引：52

作者：

Suzuki, S ^{[1
]}

Tanaka, K ^{[1
]}

Nagata, E ^{[1
]}

Ito, D ^{[1
]}

Dembo, T ^{[1
]}

Fukuuchi, Y ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Neurol, Shinjuku Ku, Tokyo 1608582, Japan

来源：

NEUROSCIENCE LETTERS | 1999年 / 262卷 / 02期

关键词：

cerebral cortex; gerbil; ischemia; hippocampus; immunohistochemistry; interleukin-6; neuron; Western blot;

D O I：

10.1016/S0304-3940(99)00051-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Markedly increased interleukin-6 (IL-6) mRNA levels occur in experimental cerebral ischemia, although the protein production and cellular sources of IL-6 remain unclear. We examined the cellular localization of IL-6 protein in gerbil brain following transient forebrain ischemia employing immunohistochemistry and Western blot analysis. The ischemia/recirculation groups revealed distinct IL-6 immunoreactivity predominantly in cortical and hippocampal neurons after 3 hours to 3 days recirculation. At 12 h recirculation, the IL-6 expression declined specifically in the hippocampus CA1. Microglia, but not activated astrocytes, also expressed IL-6 immunoreactivity. The sham group showed no apparent immunoreactivity. IL-6 protein may thus be expressed mainly in neurons following transient forebrain ischemia. Its transient decline in the CAI at 12 h recirculation could reflect the specific vulnerability of this region. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：117 / 120

页数：4

共 15 条

[1] INTERLEUKIN-6 IN BIOLOGY AND MEDICINE [J].