Vertebrate-type intron-rich genes in the marine annelid Platynereis dumerilii

被引：176

作者：

Raible, F

Tessmar-Raible, K

Osoegawa, K

Wincker, P

Jubin, C

Balavoine, G

Ferrier, D

Benes, V

de Jong, P

Weissenbach, J

Bork, P

Arendt, D

机构：

[1] European Mol Biol Lab, Dev Unit, D-69117 Heidelberg, Germany

[2] European Mol Biol Lab, Computat Unit, D-69117 Heidelberg, Germany

[3] European Mol Biol Lab, Genom Core Facil, D-69117 Heidelberg, Germany

[4] Childrens Hosp, Oakland Res Inst, Oakland, CA 94609 USA

[5] Ctr Natl Sequencage, F-91057 Evry, France

[6] CNRS, UMR 8030, F-91057 Evry, France

[7] CNRS, Ctr Genet Mol, F-91198 Gif Sur Yvette, France

[8] Univ Oxford, Dept Zool, Oxford OX1 3PS, England

来源：

SCIENCE | 2005年 / 310卷 / 5752期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1126/science.1119089

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Previous genome comparisons have suggested that one important trend in vertebrate evolution has been a sharp rise in intron abundance. By using genomic data and expressed sequence tags from the marine annelid Platynereis dumerilii, we provide direct evidence that about two-thirds of human introns predate the bilaterian radiation but were lost from insect and nematode genomes to a large extent. A comparison of coding exon sequences confirms the ancestral nature of Platynereis and human genes. Thus, the urbilaterian ancestor had complex, intron-rich genes that have been retained in Platynereis and human.

引用

页码：1325 / 1326

页数：2

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