Plant-made pharmaceuticals: Leading products and production platforms

被引：108

作者：

Paul, Matthew ^{[1
]}

Ma, Julian K-C ^{[1
]}

机构：

[1] St George Hosp, Sch Med, Div Cellular & Mol Med, London SW17 0RE, England

来源：

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY | 2011年 / 58卷 / 01期

关键词：

plant-made pharmaceuticals; plant biologic production; bioprocessing; clinical trials; biosimilars; HUMAN MONOCLONAL-ANTIBODY; HIGH-YIELD PRODUCTION; RECOMBINANT PROTEINS; TRANSIENT EXPRESSION; IDIOTYPE VACCINES; EDIBLE VACCINE; HUMAN LYSOZYME; RICE GRAINS; VIRUS; IMMUNOGENICITY;

D O I：

10.1002/bab.6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The number of approaches to recombinant protein production in plants is greater than ever before. Development of these new and improved technologies as production platforms for plant-made pharmaceuticals has and will continue to create new commercial opportunities in the pharmaceutical sector. However, it is inevitable that no single system will be optimal for the production of all recombinant proteins of interest in plants due to both the physical characteristics and the envisaged therapeutic application of each product. Here, we review a range of promising product/platform pairs emphasizing synergies during production and in clinical trials.

引用

页码：58 / 67

页数：10

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