Lipid changes in the aged brain: Effect on synaptic function and neuronal survival

被引：121

作者：

Dolores Ledesma, Maria ^{[3
]}

Martin, Mauricio G. ^{[3
]}

Dotti, Carlos G. ^{[1
,2
,3
]}

机构：

[1] Katholieke Univ Leuven VIB, Dept Mol & Dev Genet, Louvain, Belgium

[2] Katholieke Univ Leuven, Ctr Human Genet, Louvain, Belgium

[3] CSIC UAM, Ctr Biol Mol Severo Ochoa, Madrid, Spain

来源：

PROGRESS IN LIPID RESEARCH | 2012年 / 51卷 / 01期

关键词：

Aging; Brain; Lipids; Survival; Plasticity; FATTY-ACID-COMPOSITION; PROTEIN-KINASE-C; PLASMA-MEMBRANE SPHINGOMYELIN; AMPA RECEPTOR TRAFFICKING; LONG-TERM POTENTIATION; ACETYL-L-CARNITINE; DOCOSAHEXAENOIC ACID; HIPPOCAMPAL-NEURONS; ARACHIDONIC-ACID; NERVOUS-SYSTEM;

D O I：

10.1016/j.plipres.2011.11.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As the brain ages, cognitive and motor performance decline. This decline is thought to be largely due to the accumulation of damaging products from normal oxidative metabolism and to the perturbation of general body homeostasis and brain-circulation separation. Despite this abundance of insults, the aged brain contains few dead neurons, suggesting that aging must be paralleled by triggering or enhancing neuronal survival mechanisms. Recent evidence points to the contribution of changes in the lipid composition of membranes to both age-dependent cognitive decline and robust neuronal survival. In this review, we describe and discuss the current understanding of the roles of lipids in neuronal aging, with special attention to their influence on membrane fusion, neurotransmitter receptor dynamics and survival/death signaling pathways. (c) 2011 Elsevier Ltd. All rights reserved.

引用

页码：23 / 35

页数：13

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