Applicability of discovery science approach to determine biological effects of mobile phone radiation

被引:47
作者
Leszczynski, D [1 ]
Nylund, R [1 ]
Joenväärä, S [1 ]
Reivinen, J [1 ]
机构
[1] STUK Radiat & Nucl Safety Author, Radiobiol Lab, BioNIR Res Grp, FIN-00880 Helsinki, Finland
关键词
gene expression; hsp; 27; mobile phone radiation; protein expression;
D O I
10.1002/pmic.200300646
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We argue that the use of high-throughput screening techniques, although expensive and laborious, is justified and necessary in studies that examine biological effects of mobile phone radiation. The "case of hsp27 protein" presented here suggests that even proteins with only modestly altered (by exposure to mobile phone radiation) expression and activity might have an impact on cell physiology. However, this short communication does not attempt to present the full scientific evidence that is far too large to be presented in a single article and that is being prepared for publication in three separate research articles. Examples of the experimental evidence presented here were designed to show the flow of experimental process demonstrating that the use of high-throughput screening techniques might help in rapid identification of the responding proteins. This, in turn, can help in speeding up of the process of determining whether these changes might affect human health.*
引用
收藏
页码:426 / 431
页数:6
相关论文
共 11 条
  • [1] Equipping scientists for the new biology
    Aebersold, R
    Hood, LE
    Watts, JD
    [J]. NATURE BIOTECHNOLOGY, 2000, 18 (04) : 359 - 359
  • [2] Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c
    Concannon, CG
    Orrenius, S
    Samali, A
    [J]. GENE EXPRESSION, 2001, 9 (4-5): : 195 - 201
  • [3] EXPOSURE OF TUMOR-NECROSIS-FACTOR-ALPHA TO LUMINAL MEMBRANE OF BOVINE BRAIN CAPILLARY ENDOTHELIAL-CELLS COCULTURED WITH ASTROCYTES INDUCES A DELAYED INCREASE OF PERMEABILITY AND CYTOPLASMIC STRESS FIBER FORMATION OF ACTIN
    DELI, MA
    DESCAMPS, L
    DEHOUCK, MP
    CECCHELLI, R
    JOO, F
    ABRAHAM, C
    TORPIER, G
    [J]. JOURNAL OF NEUROSCIENCE RESEARCH, 1995, 41 (06) : 717 - 726
  • [4] PERMANENT CELL-LINE EXPRESSING HUMAN FACTOR-VIII-RELATED ANTIGEN ESTABLISHED BY HYBRIDIZATION
    EDGELL, CJ
    MCDONALD, CC
    GRAHAM, JB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (12): : 3734 - 3737
  • [5] *IND EXP GROUP MOB, 2000, STEW REP
  • [6] LAVOIE JN, 1993, J BIOL CHEM, V268, P24210
  • [7] Non-thermal activation of the hsp27/p38MAPK stress pathway by mobile phone radiation in human endothelial cells:: Molecular mechanism for cancer- and blood-brain barrier-related effects
    Leszczynski, D
    Joenväärä, S
    Reivinen, J
    Kuokka, R
    [J]. DIFFERENTIATION, 2002, 70 (2-3) : 120 - U1
  • [8] Mobile phones, precautionary principle, and future research
    Leszczynski, D
    [J]. LANCET, 2001, 358 (9294) : 1733 - 1733
  • [9] Hsp27 functions as a negative regulator of cytochrome c-dependent activation of procaspase-3
    Pandey, P
    Farber, R
    Nakazawa, A
    Kumar, S
    Bharti, A
    Nalin, C
    Weichselbaum, R
    Kufe, D
    Kharbanda, S
    [J]. ONCOGENE, 2000, 19 (16) : 1975 - 1981
  • [10] Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress tumor necrosis factor α by phosphorylation
    Rogalla, T
    Ehrnsperger, M
    Preville, X
    Kotlyarov, A
    Lutsch, G
    Ducasse, C
    Paul, C
    Wieske, M
    Arrigo, AP
    Buchner, J
    Gaestel, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (27) : 18947 - 18956