Submicron-scale topographical control of cell growth using holographic surface relief grating

被引:62
作者
Baac, HW
Lee, JH
Seo, JM
Park, TH
Chung, H
Lee, SD
Kim, SJ
机构
[1] Seoul Natl Univ, Nano Bioelect & Syst Res Ctr, Seoul 151742, South Korea
[2] Seoul Natl Univ, Coll Engn, Sch Chem Engn, Seoul 151742, South Korea
[3] Seoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul 151742, South Korea
[4] Seoul Natl Univ, Coll Engn, Sch Elect Engn, Seoul 151742, South Korea
来源
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS | 2004年 / 24卷 / 1-2期
关键词
topographical control; holography; cell attachment; cell orientation; photo-responsive polymer; surface relief grating;
D O I
10.1016/j.msec.2003.09.009
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
The cell orientation and attachment were controlled by a submicron-scale topographical cue. For achieving the submicron undulation of surface topography, the laser holography on a photo-responsive azobenzene copolymer layer has been employed to produce surface relief grating (SRG) which has a regular sinusoidal shape. Cultured human astrocytes (HA) were preferentially attached onto the SRG surface and highly elongated along the SRG direction. This topographical control scheme would be very efficient to control the cell growth for cellular engineering applications and to understand the interactions of the cells with a submicron-scale topographical surface. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码:209 / 212
页数:4
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