Enantioselective addition of organolithium reagents to 3,4-dihydroisoquinoline in the presence of (-)-sparteine as an external ligand. Application for the synthesis of isoquinoline alkaloids

被引：18

作者：

Chrzanowska, M ^{[1
]}

Sokolowska, J ^{[1
]}

机构：

[1] Adam Mickiewicz Univ, Fac Chem, PL-60780 Poznan, Poland

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 10期

关键词：

D O I：

10.1016/S0957-4166(01)00233-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Three isoquinoline alkaloids. (-)-salsolidine 2. (+)-carnegine 6 and (-)-1-phenyl-2-methyl-6.7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 7. were obtained in high yield and with 17-46% e.e. by the enantioselective additions of organolithium reagents to dihydroisoquinolines 1 and 5. in the presence of (-)-sparteine as a chiral ligand. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1435 / 1440

页数：6

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