Hydrogel containing hyaluronan and aliphatic oligo-carbonate moieties with tunable physical properties for potential application in protein release

被引：22

作者：

Fan, Changjiang ^{[1
]}

Tu, Jiaxing ^{[1
]}

Yang, Xiaogang ^{[1
]}

Liao, Liqiong ^{[1
]}

Liu, Lijian ^{[1
]}

机构：

[1] Wuhan Univ, Dept Polymer Sci, Wuhan 430072, Hubei, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2011年 / 86卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Photopolymerization; Hyaluronan; 2; 2-Dimethyltrimethylene carbonate; Poly(ethylene glycol); TISSUE ENGINEERING SCAFFOLDS; ACID HYDROGELS; POLY(TRIMETHYLENE CARBONATE); BIODEGRADABLE POLYMERS; CYCLIC CARBONATES; IN-VITRO; DELIVERY; DEGRADATION; BEHAVIOR; DIMETHACRYLATE;

D O I：

10.1016/j.carbpol.2011.06.048

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Hyaluronan (HA) and aliphatic oligo-carbonate based biodegradable hydrogels were synthesized via photopolymerization of a methacrylated HA(HA-GMA) with oligo(2,2-dimethyltrimethylene carbonate)-block-poly(ethylene glycol)-block -oligo(2,2-dimethyltrimethylene carbonate) diacrylate (DPD-DA). Hydrogels with tunable physical properties such as swelling behavior, crosslink density, and mesh size were fabricated with different concentrations of HA-GMA or DPD-DA. Hydrogel-bovine serum albumin (BSA) construct was prepared by in situ photopolymerization. BSA release from the construct was evaluated in vitro and the release behavior can be controlled by adjusting the concentration of the precursors. By tailoring the concentration of different precursors in the hydrogels, more sustained release of BSA can be achieved (i.e., 120 h). The cytotoxicity of this novel hydrogel was also investigated and the hydrogel proved to be comparably cytocompatible to PEG hydrogels. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1484 / 1490

页数：7

共 33 条

[1]

Influence of the degree of methacrylation on hyaluronic acid hydrogels properties [J].

Bencherif, Sidi A. ;

Srinivasan, Abiraman ;

Horkay, Ferenc ;

Hollinger, Jeffrey O. ;

Matyjaszewski, Krzysztof ;

Washburn, Newell R. .

BIOMATERIALS, 2008, 29 (12) :1739-1749

[2]

Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks [J].

Burdick, JA ;

Chung, C ;

Jia, XQ ;

Randolph, MA ;

Langer, R .

BIOMACROMOLECULES, 2005, 6 (01) :386-391

[3]

New dextrin-vinylacrylate hydrogel: Studies on protein diffusion and release [J].

Carvalho, Joana M. ;

Coimbra, Manuel A. ;

Gama, Francisco M. .

CARBOHYDRATE POLYMERS, 2009, 75 (02) :322-327

[4]

In Situ Forming Hydrogels by Tandem Thermal Gelling and Michael Addition Reaction between Thermosensitive Triblock Copolymers and Thiolated Hyaluronan [J].

Censi, Roberta ;

Fieten, Peter J. ;

di Martino, Piera ;

Hennink, Wim E. ;

Vermonden, Tina .

MACROMOLECULES, 2010, 43 (13) :5771-5778

[5]

Functions of hyaluronan in wound repair [J].

Chen, WYJ ;

Abatangelo, G .

WOUND REPAIR AND REGENERATION, 1999, 7 (02) :79-89

[6]

Flory P J., PRINCIPLES POLYM CHE

[7]

BIODEGRADABLE POLYMERS FOR PROTEIN AND PEPTIDE DRUG-DELIVERY [J].

GOMBOTZ, WR ;

PETTIT, DK .

BIOCONJUGATE CHEMISTRY, 1995, 6 (04) :332-351

[8]

Introduction of enzymatically degradable poly(trimethylene carbonate) microspheres into an injectable calcium phosphate cement [J].

Habraken, Wouter J. E. M. ;

Zhang, Zheng ;

Wolke, Joop G. C. ;

Grijpma, Dirk W. ;

Mikos, Antonios G. ;

Feijen, Jan ;

Jansen, John A. .

BIOMATERIALS, 2008, 29 (16) :2464-2476

[9]

THERMODYNAMIC INTERACTIONS IN COPOLYMERIC HYDROGELS [J].

HUGLIN, MB ;

REHAB, MMAM ;

ZAKARIA, MB .

MACROMOLECULES, 1986, 19 (12) :2986-2991

[10]

Mechanical properties and degradation behaviors of hyaluronic acid hydrogels cross-linked at various cross-linking densities [J].

Jeon, Oju ;

Song, Su Jin ;

Lee, Kee-Jung ;

Park, Moon Hyang ;

Lee, Soo-Hong ;

Hahn, Sei Kwang ;

Kim, Sungjee ;

Kim, Byung-Soo .

CARBOHYDRATE POLYMERS, 2007, 70 (03) :251-257

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