Is gliadin mispresented to the immune system in coeliac disease? A hypothesis

被引：16

作者：

Biagi, F

Zimmer, KP

Thomas, PD

Ellis, HJ

Ciclitira, PJ

机构：

[1] St Thomas Hosp, Rayne Inst, Dept Gastroenterol, Gastroentrol Unit, London SE1 7EH, England

[2] Univ Munster, Childrens Hosp, D-48149 Munster, Germany

来源：

QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS | 1999年 / 92卷 / 02期

关键词：

D O I：

10.1093/qjmed/92.2.119

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The primary pathogenic trigger in coeliac disease (CD) is still unknown. We present the hypothesis that in Co the enterocytes could metabolize gliadin through an immunogenic pathway instead of a tolerogenic one. The result of this abnormal presentation of gliadin to the immune system would be the activation of lamina propria T cells, followed by the onset of enteropathy.

引用

页码：119 / 122

页数：4

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