Are Synthetic Compounds that Silence the Liver-X-Receptor the Next Generation of Anti-cancer Drugs?

被引：11

作者：

Steffensen, Knut R. ^{[1
]}

机构：

[1] Karolinska Inst, Karolinska Univ Hosp Huddinge, Dept Lab Med, Div Clin Chem, S-14186 Stockholm, Sweden

来源：

CANCER CELL | 2015年 / 28卷 / 01期

关键词：

METABOLISM; ACTIVATION; EXPRESSION;

D O I：

10.1016/j.ccell.2015.06.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Glycolytic and lipogenic inhibitors have proven unsuccessful in cancer treatment strategies. In this issue of Cancer Cell, Flaveny and colleagues target the liver-X-receptor with an inverse agonist and show that key glycolytic and lipogenic genes are suppressed, leading to apoptosis of tumor cells without an effect on non-malignant cells.

引用

收藏

页码：3 / 4

页数：2

相关论文

共 10 条

[1]

Uncoupling Nuclear Receptor LXR and Cholesterol Metabolism in Cancer [J].

Bovenga, Fabiola ;

Sabba, Carlo ;

Moschetta, Antonio .

CELL METABOLISM, 2015, 21 (04) :517-526

[2]

Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis [J].

Flaveny, Colin A. ;

Griffett, Kristine ;

El-Gendy, Bahaa El-Dien M. ;

Kazantzis, Melissa ;

Sengupta, Monideepa ;

Amelio, Antonio L. ;

Chatterjee, Arindam ;

Walker, John ;

Solt, Laura A. ;

Kamenecka, Theodore M. ;

Burris, Thomas P. .

CANCER CELL, 2015, 28 (01) :42-56

[3]

Liver X receptor biology and pharmacology: new pathways, challenges and opportunities [J].

Jakobsson, Tomas ;

Treuter, Eckardt ;

Gustafsson, Jan-Ake ;

Steffensen, Knut R. .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2012, 33 (07) :394-404

[4]

Glycolysis inhibition for anticancer treatment [J].

Pelicano, H. ;

Martin, D. S. ;

Xu, R. -H ;

Huang, P. .

ONCOGENE, 2006, 25 (34) :4633-4646

[5]

Broad-Spectrum Therapeutic Suppression of Metastatic Melanoma through Nuclear Hormone Receptor Activation [J].

Pencheva, Nora ;

Buss, Colin G. ;

Posada, Jessica ;

Merghoub, Taha ;

Tavazoie, Sohail F. .

CELL, 2014, 156 (05) :986-1001

[6]

C75 alters central and peripheral gene expression to reduce food intake and increase energy expenditure [J].

Tu, YJ ;

Thupari, JN ;

Kim, EK ;

Pinn, ML ;

Moran, TH ;

Ronnett, GV ;

Kuhajda, FP .

ENDOCRINOLOGY, 2005, 146 (01) :486-493

[7]

Selective liver X receptor modulators (SLiMs): What use in human health? [J].

Viennois, Emilie ;

Mouzat, Kevin ;

Dufour, Julie ;

Morel, Laurent ;

Lobaccaro, Jean-Marc ;

Baron, Silvere .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2012, 351 (02) :129-141

[8]

Tumor-mediated liver X receptor-α activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses [J].

Villablanca, Eduardo J. ;

Raccosta, Laura ;

Zhou, Dan ;

Fontana, Raffaella ;

Maggioni, Daniela ;

Negro, Aurora ;

Sanvito, Francesca ;

Ponzoni, Maurilio ;

Valentinis, Barbara ;

Bregni, Marco ;

Prinetti, Alessandro ;

Steffensen, Knut R. ;

Sonnino, Sandro ;

Gustafsson, Jan-Ake ;

Doglioni, Claudio ;

Bordignon, Claudio ;

Traversari, Catia ;

Russo, Vincenzo .

NATURE MEDICINE, 2010, 16 (01) :98-U137

[9]

Identification of interferon-γ as a new molecular target of liver X receptor [J].

Wang, Qixue ;

Ma, Xingzhe ;

Chen, Yuanli ;

Zhang, Ling ;

Jiang, Meixiu ;

Li, Xiaoju ;

Xiang, Rong ;

Miao, Robert ;

Hajjar, David P. ;

Duan, Yajun ;

Han, Jihong .

BIOCHEMICAL JOURNAL, 2014, 459 :345-354

[10]

The metabolism of tumors in the body. [J].

Warburg, O ;

Wind, F ;

Negelein, E .

JOURNAL OF GENERAL PHYSIOLOGY, 1927, 8 (06) :519-530