Regional homogeneity, functional connectivity and imaging markers of Alzheimer's disease: A review of resting-state fMRI studies

被引：291

作者：

Liu, Yong ^{[1
]}

Wang, Kun ^{[1
]}

Yu, Chunshui ^{[2
]}

He, Yong ^{[1
,3
]}

Zhou, Yuan ^{[1
]}

Liang, Meng ^{[1
,4
]}

Wang, Liang ^{[2
]}

Jiang, Tianzi ^{[1
]}

机构：

[1] Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China

[2] Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China

[3] McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ H3A 2B4, Canada

[4] Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3QX, England

来源：

NEUROPSYCHOLOGIA | 2008年 / 46卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Alzheimer's disease; resting-state fMRI; ReHo; functional connectivity; biomarkers;

D O I：

10.1016/j.neuropsychologia.2008.01.027

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 [法学]; 0303 [社会学]; 030303 [人类学]; 04 [教育学]; 0402 [心理学];

摘要：

Resting-state functional magnetic resonance imaging (fMRI), a promising technique for measuring brain activities during rest, has attracted much attention in the past few years. In this paper, we review recent progress on the study of Alzheimer's disease (AD) based on resting-state fMRI. First, we briefly introduce some AD-related studies from other groups. Then we describe our AD-related work in detail from three aspects: (1) alterations in regional homogeneity (ReHo) of the fMRI signal in the resting state, (2) altered patterns of functional connectivity from regions of interest and whole brain analyses, and (3) discriminative analyses based on classification features from resting-state fMRI data for differentiating AD patients from healthy elders. Finally, we summarize the main results and some prospects for future work. (c) 2008 Published by Elsevier Ltd.

引用

页码：1648 / 1656

页数：9

共 110 条

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