Organization and function of the 3D genome

被引：646

作者：

Bonev, Boyan ^{[1
]}

Cavalli, Giacomo ^{[1
]}

机构：

[1] CNRS, Natl Ctr Sci Res, UPR1142, Inst Human Genet, 141 Rue Cardonille, F-34396 Montpellier 5, France

来源：

NATURE REVIEWS GENETICS | 2016年 / 17卷 / 11期

基金：

欧盟地平线“2020”;

关键词：

INACTIVE X-CHROMOSOME; HIGH-RESOLUTION; CHROMATIN ARCHITECTURE; GENE-EXPRESSION; SPATIAL-ORGANIZATION; TOPOLOGICAL DOMAINS; CTCF BINDING; HOX GENES; COHESIN; REORGANIZATION;

D O I：

10.1038/nrg.2016.112

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Understanding how chromatin is organized within the nucleus and how this 3D architecture influences gene regulation, cell fate decisions and evolution are major questions in cell biology. Despite spectacular progress in this field, we still know remarkably little about the mechanisms underlying chromatin structure and how it can be established, reset and maintained. In this Review, we discuss the insights into chromatin architecture that have been gained through recent technological developments in quantitative biology, genomics and cell and molecular biology approaches and explain how these new concepts have been used to address important biological questions in development and disease.

引用

页码：661 / 678

页数：18

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