Centrosome clustering and chromosomal (in)stability: A matter of life and death

被引：90

作者：

Kraemer, Alwin ^{[1
]}

Maier, Bettina ^{[1
]}

Bartek, Jiri ^{[2
,3
,4
]}

机构：

[1] Heidelberg Univ, German Canc Res Ctr, Clin Cooperat Unit Mol Hematol Oncol, Dept Internal Med 5, D-69120 Heidelberg, Germany

[2] Danish Canc Soc, Inst Canc Biol, Copenhagen, Denmark

[3] Danish Canc Soc, Ctr Genotox Stress Res, Copenhagen, Denmark

[4] Palacky Univ, Inst Mol & Translat Med, CR-77147 Olomouc, Czech Republic

来源：

MOLECULAR ONCOLOGY | 2011年 / 5卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

Centrosome clustering; Chromosomal instability; Multipolarity; Mitosis; DNA damage; Stem cells; INTEGRIN-LINKED KINASE; CENTROMERE-ASSOCIATED KINESIN; CELL LUNG-CANCER; AURORA-B KINASE; EXTRA CENTROSOMES; INNER CENTROMERE; INSTABILITY; PROTEIN; GRISEOFULVIN; DNA;

D O I：

10.1016/j.molonc.2011.05.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Centrosome abnormalities occur commonly in cancer, and contribute to chromosomal instability and tumorigenesis. New evidence on a phylogenetically conserved mechanism termed 'centrosomal clustering' provides exciting insights into how cells with supernumerary centrosomes adapt to avoid lethal multipolar divisions. Here, we highlight the emerging molecular basis of centrosome clustering, and its impact on asymmetric divisions of stem cells, chromosomal (in)stability and malignant transformation. Finally, pharmacological inhibition of centrosome clustering promises to selectively target tumor cells. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：324 / 335

页数：12

共 114 条

[1] Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells [J].