Bone reconstruction: Au nanocomposite bioglasses with antibacterial properties

被引：23

作者：

Grandi, Stefania ^{[2
]}

Cassinelli, Valentina ^{[2
]}

Bini, Marcella ^{[2
]}

Saino, Enrica ^{[1
,3
]}

Mustarelli, Piercarlo ^{[2
,3
]}

Arciola, Carla Renata ^{[4
]}

Imbriani, Marcello ^{[5
]}

Visai, Livia ^{[1
,3
,6
]}

机构：

[1] Univ Pavia, Dept Mol Med, I-27100 Pavia, Italy

[2] Univ Pavia, Dept Chem, I-27100 Pavia, Italy

[3] Ctr Tissue Engn CIT, Pavia, Italy

[4] Univ Bologna, Dept Expt Pathol, Rizzoli Orthoped Inst, Res Unit Implant Infect, I-40126 Bologna, Italy

[5] Salvatore Maugeri Fdn IRCCS, Dept Publ Hlth & Neurosci, Pavia, Italy

[6] Int Ctr Studies & Res Biomed ICB, Luxembourg, Luxembourg

来源：

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS | 2011年 / 34卷 / 09期

关键词：

Bioglass; Gold nanoparticles; Sol-gel; Antibacterial activity; SOL-GEL GLASS; BIOACTIVE GLASSES; SILVER NANOPARTICLES; GENTAMICIN RELEASE; MORPHOLOGY; CERAMICS; MODEL; AMINO; OXIDE;

D O I：

10.5301/ijao.5000059

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Bioglasses are of wide interest since they spontaneously bond and integrate with living bone in the body. By varying the glass chemistry and/or by adding some dopants, it is possible to improve their clinical applications. Gold nanoparticles (Au NPs) are a well-known antibacterial agent, as well as a unique probe for sensing and imaging applications. We report on the synthesis of a 58S bioglass doped with Au NPs at two doping levels: 0.1% wt. and 1% wt. Antibacterial properties were observed on the Gram-positive Staphylococcus aureus, whereas no significant effects were found on the Gram-negative Escherichia coli. A possible mechanism of action of Au NPs towards bacteria has been described.

引用

页码：920 / 928

页数：9

共 38 条

[1] Functionalization of Sol Gel Bioactive Glasses Carrying Au Nanoparticles: Selective Au Affinity for Amino and Thiol Ligand Groups [J].