Compositional heterogeneity within and among isochores in mammalian genomes - II. Some general comments

被引：16

作者：

Clay, O ^{[1
]}

Bernardi, G ^{[1
]}

机构：

[1] Staz Zool Anton Dohrn, Lab Mol Evolut, I-80121 Naples, Italy

来源：

GENE | 2001年 / 276卷 / 1-2期

关键词：

analytical ultracentrifugation; base composition; DNA; homogeneity; long-range correlations;

D O I：

10.1016/S0378-1119(01)00668-0

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The presence of long-range correlations and/or mosaicism in DNA sequences results in GC fluctuations, even within individual isochores that are much larger than expected correlation-free 'random' sequences. Neglecting the presence of such fluctuations can lead to incorrect conclusions regarding relative homogeneity or isochore borders. ln this commentary, we address these and other methodological issues raised by the variations in GC level within human isochores. We also discuss some recent misconceptions. (C) 2001 Published by Elsevier Science B.V.

引用

页码：25 / 31

页数：7

共 36 条

[1] Beran J, 1994, STAT LONG MEMORY PRO
[2] Compositional segmentation and long-range fractal correlations in DNA sequences
BernaolaGalvan, P
RomanRoldan, R
Oliver, JL
[J]. PHYSICAL REVIEW E, 1996, 53 (05): : 5181 - 5189
[3] Isochores and the evolutionary genomics of vertebrates
Bernardi, G
[J]. GENE, 2000, 241 (01) : 3 - 17
[4] BOURBAKI N, 1969, FASCICULES ELEMENTS
[5] Long-range sequence analysis in Xq28: Thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and GGPD loci
Chen, EY
Zollo, M
Mazzarella, R
Ciccodicola, A
Chen, CN
Zuo, L
Heiner, C
Burough, F
Repetto, M
Schlessinger, D
DUrso, M
[J]. HUMAN MOLECULAR GENETICS, 1996, 5 (05) : 659 - 668
[6] The isochores in human chromosomes 21 and 22
Clay, O
Bernardi, G
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 285 (04) : 855 - 856
[7] Standard deviations and correlations of GC levels in DNA sequences
Clay, O
[J]. GENE, 2001, 276 (1-2) : 33 - 38
[8] Compositional heterogeneity within and among isochores in mammalian genomes - I. CsCl and sequence analyses
Clay, O
Carels, N
Douady, C
Macaya, G
Bernardi, G
[J]. GENE, 2001, 276 (1-2) : 15 - 24
[9] THE MAJOR COMPONENTS OF THE MOUSE AND HUMAN GENOMES .1. PREPARATION, BASIC PROPERTIES AND COMPOSITIONAL HETEROGENEITY
CUNY, G
SORIANO, P
MACAYA, G
BERNARDI, G
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1981, 115 (02): : 227 - 233
[10] A compositional map of the cen-q21 region of human chromosome 21
DeSario, A
Roizes, G
Allegre, N
Bernardi, G
[J]. GENE, 1997, 194 (01) : 107 - 113

← 1 2 3 4 →