A method for preparing C-glycosides related to phlorizin

被引：47

作者：

Link, JT ^{[1
]}

Sorensen, BK ^{[1
]}

机构：

[1] Abbott Labs, Abbott Pk, IL 60064 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 48期

关键词：

D O I：

10.1016/S0040-4039(00)01709-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Johnson's Suzuki coupling protocol was employed to prepare C-glycoside analogs of phlorizin (1). In vitro biological evaluation of these C-glycosides indicated the anomeric oxygen is important to the SGLT inhibitory activity of phlorizin (1) and related agents, (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：9213 / 9217

页数：5

共 19 条

[1]

ALVARADO F, 1962, BIOCHIM BIOPHYS ACTA, V56, P170, DOI 10.1016/0006-3002(62)90543-7

[2] STUDIES ON MECHANISM OF INTESTINAL ABSORPTION OF SUGARS .7. PHENYLGLYCOSIDE TRANSPORT + ITS POSSIBLE RELATIONSHIP TO PHLORIZIN INHIBITION OF ACTIVE TRANSPORT OF SUGARS BY SMALL INTESTINE [J].