Characterization of a divergent vanD-type resistance element from the first glycopeptide-resistant strain of Enterococcus faecium isolated in Brazil

被引：37

作者：

Dalla Costa, LM

Reynolds, PE

Souza, HAPHM

Souza, DC

Palepou, MFI

Woodford, N

机构：

[1] Cent Publ Hlth Lab, Antibiot Resistance Monitoring & Reference Lab, London NW9 5HT, England

[2] Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

[3] Univ Fed Parana, Hosp Clin, BR-80060000 Curitiba, Parana, Brazil

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 12期

关键词：

D O I：

10.1128/AAC.44.12.3444-3446.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Enterococcus faecium 10/96A from Brazil was resistant to vancomycin (MIC, 256 mug/ml) but gave no amplification products with primers specific for known van genotypes. A 2,368-bp fragment of a van cluster contained one open reading frame encoding a peptide with 83% amino acid identity to VanH(D), and a second encoding a D-alanine-D-lactate ligase with 83 to 85% identity to VanD. The divergent glycopeptide resistance phenotype was designated VanD4.

引用

页码：3444 / 3446

页数：3

共 20 条

[1] Characterization and modelling of VanT:: a novel, membrane-bound, serine racemase from vancomycin-resistant Enterococcus gallinarum BM4174
Arias, CA
Martín-Martinez, M
Blundell, TL
Arthur, M
Courvalin, P
Reynolds, PE
[J]. MOLECULAR MICROBIOLOGY, 1999, 31 (06) : 1653 - 1664
[2] Requirement of the VanY and VanX D,D-peptidases for glycopeptide resistance in enterococci
Arthur, M
Depardieu, F
Cabanié, L
Reynolds, P
Courvalin, P
[J]. MOLECULAR MICROBIOLOGY, 1998, 30 (04) : 819 - 830
[3] Boyd DA, 2000, J CLIN MICROBIOL, V38, P2392
[4] Characterization of the vanD glycopeptide resistance gene cluster from Entercoccus faecium BM4339
Casadewall, B
Courvalin, P
[J]. JOURNAL OF BACTERIOLOGY, 1999, 181 (12) : 3644 - 3648
[5] Heterogeneity in the vanB gene cluster of genomically diverse clinical strains of vancomycin-resistant enterococci
Dahl, KH
Simonsen, GS
Olsvik, O
Sundsfjord, A
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (05) : 1105 - 1110
[6] DALLACOSTA LM, 1998, J INFECT DIS, V2, P160
[7] VanE, a new type of acquired glycopeptide resistance in Enterococcus faecalis BM4405
Fines, M
Perichon, B
Reynolds, P
Sahm, DF
Courvalin, P
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (09) : 2161 - 2164
[8] A GENE CONFERRING RESISTANCE TO VANCOMYCIN BUT NOT TEICOPLANIN IN ISOLATES OF ENTEROCOCCUS-FAECALIS AND ENTEROCOCCUS-FAECIUM DEMONSTRATES HOMOLOGY WITH VANB, VANA, AND VANC GENES OF ENTEROCOCCI
GOLD, HS
UNAL, S
CERCENADO, E
THAUVINELIOPOULOS, C
ELIOPOULOS, GM
WENNERSTEN, CB
MOELLERING, RC
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (08) : 1604 - 1609
[9] Vancomycin resistance in enterococci: reprogramming of the D-Ala-D-Ala ligases in bacterial peptidoglycan biosynthesis
Healy, VL
Lessard, IAD
Roper, DI
Knox, JR
Walsh, CT
[J]. CHEMISTRY & BIOLOGY, 2000, 7 (05): : R109 - R119
[10] First report of vancomycin-resistant Enterococcus faecium isolated in Argentina
Marín, ME
Mera, JR
Arduino, RC
Correa, AP
Coque, TM
Stamboulian, D
Murray, BE
[J]. CLINICAL INFECTIOUS DISEASES, 1998, 26 (01) : 235 - 236

← 1 2 →