Endoglin (CD105): a powerful therapeutic target on tumor-associated angiogenetic blood vessels

被引：214

作者：

Fonsatti, E

Altomonte, M

Nicotra, MR

Natali, PG

Maio, M

机构：

[1] IRCCS, Ctr Riferimento Oncol, Dept Med Oncol, Canc Bioimmunotherapy Unit, I-33081 Aviano, Italy

[2] CNR, Ist Biol & Patol Mol, I-00156 Rome, Italy

[3] Ist Regina Elena, Ctr Ric Sperimentale, Immunol Lab, I-00158 Rome, Italy

来源：

ONCOGENE | 2003年 / 22卷 / 42期

关键词：

angiogenesis; CD105; endoglin; endothelial cells; soluble CD105; transforming growth factor;

D O I：

10.1038/sj.onc.1206813

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Among surface molecules expressed on endothelial cells, endoglin (CD105) is emerging as a prime vascular target for antiangiogenetic cancer therapy. CD105 is a cell membrane glycoprotein mainly expressed on endothelial cells and overexpressed on tumor-associated vascular endothelium, which functions as an accessory component of the transforming growth factor -beta receptor complex and is involved in vascular development and remodelling. Quanti. cation of intratumoral microvessel density by CD105 staining and of circulating soluble CD105 has been suggested to have prognostic significance in selected neoplasias. In addition, the potential usefulness of CD105 in tumor imaging and antiangiogenetic therapy has been well documented utilizing different animal models.

引用

收藏

页码：6557 / 6563

页数：7

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