Baicalein prevents 6-hydroxydopamine-induced dopaminergic dysfunction and lipid peroxidation in mice

被引：39

作者：

Im, HI

Joo, WS

Nam, E

Lee, ES

Hwang, YJ

Kim, YS ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Med, Dept Pharmacol, Seoul 110799, South Korea

[2] Seoul Natl Univ, Neurosci Res Inst, Med Res Ctr, Seoul 110799, South Korea

[3] Korea Food & Drug Adm, Div Biol Evaluat, Seoul 122704, South Korea

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2005年 / 98卷 / 02期

关键词：

6-hydroxydopamine; baicalein; tyrosine hydroxylase;

D O I：

10.1254/jphs.SC0050014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of baicalein on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity were evaluated. Intracerebroventricularly (i.c.v.) injection of 6-OHDA was done to young mice. Baicalein was administered intraperitoneally 30 min before and 90 min after i.c.v. injection. Animals received further injection of bacalcin daily for 3 consecutive days. Rotarod performance was assessed, tyrosine hydroxylase (TH) Western blotting was performed, and dopamine (DA) levels and peroxidation were determined. High dose of baicalein effectively improved rotarod performance and prevented the reduction of striatal DA levels and TH contents in the striatum and subtantia nigra (SN). In addition, lipid peroxidation level was decreased by baicalein at 3 and 7 days after 6-OHDA injection. These results showed that baicalein effectively prevents the 6-OHDA-induced dopaminergic dysfunction through an antioxidative action.

引用

页码：185 / 189

页数：5

共 15 条

[1] Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) [J].