DEVELOPMENT OF ANXIETY: THE ROLE OF THREAT APPRAISAL AND FEAR LEARNING

被引:216
作者
Britton, Jennifer C. [1 ]
Lissek, Shmuel [1 ]
Grillon, Christian [1 ]
Norcross, Maxine A. [1 ]
Pine, Daniel S. [1 ]
机构
[1] NIMH, Mood & Anxiety Disorders Program, Bethesda, MD 20892 USA
基金
美国国家卫生研究院;
关键词
fear conditioning; generalization; attention; amygdala; ventromedial prefrontal cortex; MEDIAL PREFRONTAL CORTEX; POSTTRAUMATIC-STRESS-DISORDER; CONDITIONED FEAR; AMYGDALA RESPONSE; POTENTIATED STARTLE; D-CYCLOSERINE; EMOTIONAL REACTIVITY; COGNITIVE REGULATION; ATTENTIONAL BIAS; NEGATIVE AFFECT;
D O I
10.1002/da.20733
中图分类号
B849 [应用心理学];
学科分类号
040203 [应用心理学];
摘要
Anxious individuals exhibit threat biases at multiple levels of information processing. From a developmental perspective, abnormal safety learning in childhood may establish threat-related appraisal biases early, which may contribute to chronic disorders in adulthood. This review illustrates how the interface among attention, threat appraisal, and fear learning can generate novel insights for outcome prediction. This review summarizes data on amygdala function, as it relates to learning and attention, highlights the importance of examining threat appraisal, and introduces a novel imaging paradigm to investigate the neural correlates of threat appraisal and threat-sensitivity during extinction recall. This novel paradigm can be used to investigate key questions relevant to prognosis and treatment. Depression and Anxiety 28:5-17, 2011. (C) 2010 Wiley-Liss, Inc.
引用
收藏
页码:5 / 17
页数:13
相关论文
共 129 条
[1]
Meeting of minds: the medial frontal cortex and social cognition [J].
Amodio, DM ;
Frith, CD .
NATURE REVIEWS NEUROSCIENCE, 2006, 7 (04) :268-277
[2]
[Anonymous], 2000, Neural systems involved in fear inhibition: extinction and conditioned inhibition, DOI 10.1007/978-1-4757-4860-4_8
[3]
[Anonymous], 1941, Conditioned reflexes and psychiatry
[4]
Bachevalier J, 2001, DEV COGN NEUROSCI, P365
[5]
Threat-related attentional bias in anxious and nonanxious individuals: A meta-analytic study [J].
Bar-Haim, Yair ;
Lamy, Dominique ;
Pergamin, Lee ;
Bakermans-Kranenburg, Marian J. ;
van IJzendoorn, Marinus H. .
PSYCHOLOGICAL BULLETIN, 2007, 133 (01) :1-24
[6]
Incidence of social anxiety disorder and the consistent risk for secondary depression in the first three decades of life [J].
Beesdo, Katja ;
Bittner, Antje ;
Pine, Daniel S. ;
Stein, Murray B. ;
Hoefler, Michael ;
Lieb, Roselind ;
Wittchen, Hans-Ulrich .
ARCHIVES OF GENERAL PSYCHIATRY, 2007, 64 (08) :903-912
[7]
Common and Distinct Amygdala-Function Perturbations in Depressed vs Anxious Adolescents [J].
Beesdo, Katja ;
Lau, Jennifer Y. F. ;
Guyer, Amanda E. ;
McClure-Tone, Erin B. ;
Monk, Christopher S. ;
Nelson, Eric E. ;
Fromm, Stephen J. ;
Goldwin, Michelle A. ;
Wittchen, Hans-Ulrich ;
Leibenluft, Ellen ;
Erns, Monique ;
Pine, Daniel S. .
ARCHIVES OF GENERAL PSYCHIATRY, 2009, 66 (03) :275-285
[8]
State anxiety modulation of the amygdala response to unattended threat-related stimuli [J].
Bishop, SJ ;
Duncan, J ;
Lawrence, AD .
JOURNAL OF NEUROSCIENCE, 2004, 24 (46) :10364-10368
[9]
Amygdala temporal dynamics: temperamental differences in the timing of amygdala response to familiar and novel faces [J].
Blackford, Jennifer U. ;
Avery, Suzanne N. ;
Shelton, Richard C. ;
Zald, David H. .
BMC NEUROSCIENCE, 2009, 10
[10]
Blanchard DC, 2001, NEUROSCI BIOBEHAV R, V25, P761