Murine model of chronic human asthma

被引：38

作者：

Kumar, RK ^{[1
]}

Foster, PS

机构：

[1] Univ New S Wales, Sch Pathol, Inflammat Res Unit, Sydney, NSW 2052, Australia

[2] Australian Natl Univ, John Curtin Sch Med Res, Div Biochem & Mol Biol, Canberra, ACT 2601, Australia

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2001年 / 79卷 / 02期

关键词：

animal model; asthma; chronic inflammation; remodelling;

D O I：

10.1046/j.1440-1711.2001.00981.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Human asthma is associated with acute and chronic inflammation of the airway mucosa, accompanied by airway wall remodelling. Experimental models of acute allergic bronchopulmonary inflammation in mice are useful for investigation of immunological mechanisms and of cellular recruitment, but have significant limitations because they fail to reproduce a number of characteristic lesions of human asthma, while usually being associated with marked alveolitis. We have developed an improved murine model of asthma that exhibits almost all of the morphological and functional changes that typify the human disease, without any confounding alveolitis. This model has considerable potential for the investigation of pathogenetic mechanisms and potential treatments of chronic human asthma.

引用

页码：141 / 144

页数：4

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