Age-Related Macular Degeneration and the Other Double Helix The Cogan Lecture

被引：25

作者：

Ambati, Jayakrishna ^{[1
]}

机构：

[1] Univ Kentucky, Dept Ophthalmol & Vis Sci, Lexington, KY USA

来源：

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2011年 / 52卷 / 05期

基金：

美国国家卫生研究院;

关键词：

TOLL-LIKE RECEPTOR-3; SMALL INTERFERING RNAS; DOUBLE-STRANDED-RNA; EXPERIMENTAL CHOROIDAL NEOVASCULARIZATION; IN-VIVO DELIVERY; NF-KAPPA-B; OCULAR NEOVASCULARIZATION; BINDING-SITE; MOUSE MODEL; SIRNA;

D O I：

10.1167/iovs.11-7328

中图分类号：

R77 [眼科学];

学科分类号：

100212 [眼科学];

摘要：

The study and therapy of age-related macular degeneration (AMD), a leading cause of blindness worldwide, have taken great strides over the past decade. During the same time, a central role for RNA in many human diseases has been discovered. We have identified anti-angiogenic functions for synthetic double stranded RNAs (dsRNAs) in neovascular AMD and cytotoxic functions for endogenous dsRNAs in atrophic AMD. These findings provide new insights into the pathogenesis and therapy of both forms of AMD. (Invest Ophthalmol Vis Sci. 2011;52:2166-2169) DOI:10.1167/iovs.11-7328

引用

页码：2166 / 2169

页数：4

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