The cancer stem cell hypothesis: a work in progress

被引：225

作者：

Tan, Brenton Thomas ^{[1
]}

Park, Christopher Yongchul ^{[1
]}

Ailles, Laurie Elizabeth ^{[1
]}

Weissman, Irving L. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA

来源：

LABORATORY INVESTIGATION | 2006年 / 86卷 / 12期

关键词：

hematopoiesis; neoplasm; transplantation; stem cells; tumor;

D O I：

10.1038/labinvest.3700488

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

There is a growing body of evidence that supports the idea that malignant tumors are initiated and maintained by a population of tumor cells that share similar biologic properties to normal adult stem cells. This model, the cancer stem cell (CSC) hypothesis, is based on the observation that tumors, like adult tissues, arise from cells that exhibit the ability to self-renew as well as give rise to differentiated tissue cells. Although the concept of the CSC is not entirely new, advances made over the past two decades in our understanding of normal stem cell biology in conjunction with the recent application of these concepts to experimentally define CSCs have resulted in the identification of CSCs in several human malignancies.

引用

页码：1203 / 1207

页数：5

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