A patient with neuro-Behcet's disease is successfully treated with etanercept:: Further evidence for the value of TNFα blockade

被引：39

作者：

Alty, Jane E. ^{[1
]}

Monaghan, Tanya M. ^{[1
]}

Bamford, John M. ^{[1
]}

机构：

[1] Gen Infirm, Dept Neurol, Leeds LS1 3EX, W Yorkshire, England

来源：

CLINICAL NEUROLOGY AND NEUROSURGERY | 2007年 / 109卷 / 03期

关键词：

neuro-Behcet's; Behcet's; etanercept; infliximab; TNF alpha; treatment; monoclonal antibodies;

D O I：

10.1016/j.clineuro.2006.11.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Behcet's disease is a chronic relapsing multisystem vasculitis with 49% of cases involving the CNS. Recently there have been two reports of neuro-Behcet's disease (NB) successfully treated with the tumour necrosis factor alpha (TNF alpha) monoclonal antibody infliximab. We describe a patient with longstanding NB who was poorly responsive to azathioprine, cyclosporin, thalidomide and methotrexate. She showed a remarkable response when treated with the recombinant human TNF alpha receptor protein, etanercept. To the best of our knowledge this is the first report of NB successfully treated with etanercept. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：279 / 281

页数：3

共 6 条

[1]

Clinical patterns of neurological involvement in Behcet's disease:: evaluation of 200 patients [J].

Akman-Demir, G ;

Serdaroglu, P ;

Tasçi, B .

BRAIN, 1999, 122 :2171-2181

[2]

Manifestations of Neuro-Behcet's disease - Report of two cases and review of the literature [J].

Ho, CL ;

Deruytter, MJ .

CLINICAL NEUROLOGY AND NEUROSURGERY, 2005, 107 (04) :310-314

[3]

MEGE JL, 1993, J RHEUMATOL, V20, P1544

[4]

Tumour necrosis factor inhibitors [J].

Nash, PT ;

Florin, THJ .

MEDICAL JOURNAL OF AUSTRALIA, 2005, 183 (04) :205-208

[5]

Efficacy of TNF a blockade in cyclophosphamide resistant neuro-Behcet disease [J].

Ribi, C ;

Sztajzel, R ;

Delavelle, J ;

Chizzolini, C .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2005, 76 (12) :1733-1735

[6]

Sarwar H, 2005, J RHEUMATOL, V32, P181

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