Dietary polyphenols: Good, bad, or indifferent for your health?

被引：382

作者：

Halliwell, Barry ^{[1
]}

机构：

[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117597, Singapore

来源：

CARDIOVASCULAR RESEARCH | 2007年 / 73卷 / 02期

关键词：

atherosclerosis; cell culture/isolation; redox signalling;

D O I：

10.1016/j.cardiores.2006.10.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Flavonoids and other polyphenolic compounds have powerful antioxidant effects in vitro in many test systems, but can act as pro-oxidants in some others. Whether pro-oxidant, antioxidant, or any of the many other biological effects potentially exerted by flavonoids account for or contribute to the health benefits of diets rich in plant-derived foods and beverages is uncertain. Phenolic compounds may help to protect the gastrointestinal tract against damage by reactive species present in foods or generated within the stomach and intestines. The overall health benefit of flavonoids is uncertain, and consumption of large quantities of them in fortified foods or supplements should not yet be encouraged. (c) 2006 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

引用

页码：341 / 347

页数：7

共 114 条

[1] Inhibition of angiotensin converting enzyme activity by flavanol-rich foods [J].

Actis-Goretta, L ;

Ottaviani, JI ;

Fraga, CG .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2006, 54 (01) :229-234

[2] Production of hydrogen peroxide by polyphenols and polyphenol-rich beverages under quasi-physiological conditions [J].

Akagawa, M ;

Shigemitsu, T ;

Suyama, K .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2003, 67 (12) :2632-2640

[3] Inhibition of advanced glycation endproduct formation by acetaldehyde: Role in the cardioprotective effect of ethanol [J].

Al-Abed, Y ;

Mitsuhashi, T ;

Li, HW ;

Lawson, JA ;

FitzGerald, GA ;

Founds, H ;

Donnelly, T ;

Cerami, A ;

Ulrich, P ;

Bucala, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (05) :2385-2390

[4] Role of hydrogen peroxide in bactericidal action of catechin [J].

Arakawa, H ;

Maeda, M ;

Okubo, S ;

Shimamura, T .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2004, 27 (03) :277-281

[5]

August DA, 1999, CANCER EPIDEM BIOMAR, V8, P709

[6]

Aviram M, 2002, DRUG EXP CLIN RES, V28, P49

[7] Intestinal glutathione: determinant of mucosal peroxide transport, metabolism, and oxidative susceptibility [J].

Aw, TY .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2005, 204 (03) :320-328

[8] FREE-RADICALS AND THE ETIOLOGY OF COLON CANCER [J].

BABBS, CF .

FREE RADICAL BIOLOGY AND MEDICINE, 1990, 8 (02) :191-200

[9] Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis [J].

Bjelakovic, G ;

Nikolova, D ;

Simonetti, RG ;

Gluud, C .

LANCET, 2004, 364 (9441) :1219-1228

[10] Dietary folate from vegetables and citrus fruit decreases plasma homocysteine concentrations in humans in a dietary controlled trial [J].

Brouwer, IA ;

van Dusseldorp, M ;

West, CE ;

Meyboom, S ;

Thomas, CMG ;

Duran, M ;

Hof, KHV ;

Eskes, TKAB ;

Hautvast, JGAJ ;

Steegers-Theunissen, RPM .

JOURNAL OF NUTRITION, 1999, 129 (06) :1135-1139

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