Postmenopausal women with osteoporosis may be associated with high endothelin-1

被引:20
作者
Gulhan, Ibrahim [1 ]
Kebapcilar, Levent [2 ]
Alacacioglu, Ahmet
Bilgili, Sibel [3 ]
Kume, Tuncay [4 ]
Aytac, Bilal [5 ]
Gunaydin, Rezzan [6 ]
机构
[1] Izmir Res & Training Hosp, Dept Gynecol & Obstet, Izmir, Turkey
[2] Izmir Res & Training Hosp, Dept Internal Med, Div Endocrinol & Metab, Izmir, Turkey
[3] Izmir Res & Training Hosp, Dept Biochem, Izmir, Turkey
[4] Dokuz Eylul Univ, Dept Biochem, Izmir, Turkey
[5] Minist Hlth, Directorate Curat Serv, Ankara, Turkey
[6] Izmir Res & Training Hosp, Dept Phys Therapy & Rehabil, Izmir, Turkey
关键词
Osteoporosis; postmenopausal women; endothelin-1; asymmetrical dimethyl arginine; ASYMMETRIC DIMETHYLARGININE; BONE; CELL; EXPRESSION;
D O I
10.1080/09513590903015429
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Aim. We aimed to find out if there was any difference of the endothelin-1 (ET-1) and asymmetric dimethylarginine (ADMA) levels between osteoporotic and non-osteoporotic healthy postmenopausal women and whether there were any associations between ET-1 and ADMA levels and bone mineral density (BMD). Methods. A total of 75 healthy postmenopausal women were enrolled in the study. BMD was measured at lumbar spine (LS) and femur neck (FN). Serum ET-1 and ADMA levels were measured by ELISA. In this population, 41 (54%) women had BMD t-scores >= 2.5 at the LS and/or FN defined as osteoporosis and 34 (46%) of them had normal BMDs (non-osteoporotic group). Results. The mean value of ET-1 serum level in patients was 0.42 +/- 0.30, 0.28 +/- 0.12 fmol/ml in osteoporotic and non-osteoporotic groups, respectively (p = 0.018). In non-osteoporotic group, there was an only significant positive correlation was found between BMD (g/cm(2)) and total t-scores at the lumbar region and ET-1 level. In osteoporotic group, no correlation was found between BMD and total t-scores and ET-1 levels. Serum ADMA level was not significantly different between osteoporotic and non-osteoporotic postmenopausal women (p > 0.05). Conclusions. ET-1 may be a physiologic regulator in non-osteoporotic healthy postmenopausal women. Osteoporotic postmenopausal women had higher ET-1 levels than non-osteoporotic postmenopausal women. ADMA seems not to have effect on bone in postmenopausal women.
引用
收藏
页码:674 / 678
页数:5
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