Direct cadherin-activated cell signaling: a view from the plasma membrane

被引：249

作者：

Yap, AS ^{[1
]}

Kovacs, EM

机构：

[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

[2] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia

来源：

JOURNAL OF CELL BIOLOGY | 2003年 / 160卷 / 01期

基金：

英国惠康基金;

关键词：

cadherin; Rac; actin cytoskeleton; Rho GTPase; PI3; kinase;

D O I：

10.1083/jcb.200208156

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Classical cadherin adhesion molecules are key determinants of cell recognition and tissue morphogenesis, with diverse effects on cell behavior. Recent developments indicate that classical cadherins are adhesion-activated signaling receptors. In particular, early-immediate Rac signaling is emerging as a mechanism to coordinate cadherin-actin integration at the plasma membrane.

引用

页码：11 / 16

页数：6

共 49 条

[1] Cytomechanics of cadherin-mediated cell-cell adhesion
Adams, CL
Nelson, WJ
[J]. CURRENT OPINION IN CELL BIOLOGY, 1998, 10 (05) : 572 - 577
[2] Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high-resolution tracking of E-cadherin-green fluorescent protein
Adams, CL
Chen, YT
Smith, SJ
Nelson, WJ
[J]. JOURNAL OF CELL BIOLOGY, 1998, 142 (04) : 1105 - 1119
[3] Inhibition of RhoA by p120 catenin
Anastasiadis, PZ
Moon, SY
Thoreson, MA
Mariner, DJ
Crawford, HC
Zheng, Y
Reynolds, AB
[J]. NATURE CELL BIOLOGY, 2000, 2 (09) : 637 - 644
[4] Epithelial cell shape: Cadherins and small GTPases
Braga, V
[J]. EXPERIMENTAL CELL RESEARCH, 2000, 261 (01) : 83 - 90
[5] Regulation of cadherin function by Rho and Rac: Modulation by junction maturation and cellular context
Braga, VMM
Del Maschio, A
Machesky, L
Dejana, E
[J]. MOLECULAR BIOLOGY OF THE CELL, 1999, 10 (01) : 9 - 22
[6] REGULATION OF C-CADHERIN FUNCTION DURING ACTIVIN INDUCED MORPHOGENESIS OF XENOPUS ANIMAL CAPS
BRIEHER, WM
GUMBINER, BM
[J]. JOURNAL OF CELL BIOLOGY, 1994, 126 (02) : 519 - 527
[7] Lateral dimerization is required for the homophilic binding activity of C-cadherin
Brieher, WM
Yap, AS
Gumbiner, BM
[J]. JOURNAL OF CELL BIOLOGY, 1996, 135 (02) : 487 - 496
[8] Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
Carmeliet, P
Lampugnani, MG
Moons, L
Breviario, F
Compernolle, V
Bono, F
Balconi, G
Spagnuolo, R
Oosthuyse, B
Dewerchin, M
Zanetti, A
Angellilo, A
Mattot, V
Nuyens, D
Lutgens, E
Clotman, F
de Ruiter, MC
Gittenberger-de Groot, A
Poelmann, R
Lupu, F
Herbert, JM
Collen, D
Dejana, E
[J]. CELL, 1999, 98 (02) : 147 - 157
[9] N-cadherin-dependent cell-cell contact regulates Rho GTPases and β-catenin localization in mouse C2C12 myoblasts
Charrasse, S
Meriane, M
Comunale, F
Blangy, A
Gauthier-Rouvière, C
[J]. JOURNAL OF CELL BIOLOGY, 2002, 158 (05) : 953 - 965
[10] Rac1 protects epithelial cells against anoikis
Coniglio, SJ
Jou, TS
Symons, M
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (30) : 28113 - 28120

← 1 2 3 4 5 →